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| 15.05.2022 | 14:00 | USV Hercules | - | RKSV Groene Ster | 3:1 (2:1) | |
| 14:00 | VV Hoogland | - | ADO '20 | 1:2 (0:2) | ||
| 14:00 | VV Dongen | - | OSS '20 | 1:2 (1:1) | ||
| 14:00 | HVV Hollandia | - | Blauw Geel '38 | 1:1 (0:1) | ||
| 14:00 | RKVV DEM | - | RKVV Westlandia | 3:2 (1:0) | ||
| 14:00 | JOS Watergraafsmeer | - | VV UNA | 1:3 (1:0) | ||
| 14:00 | VV Gemert | - | EVV | 3:4 (1:1) | ||
| 14:30 | HSC'21 | - | Quick Den Haag | 3:3 (1:2) | ||
| 14:30 | OFC Oostzaan | - | Unitas Gorinchem | 0:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 30 | 15 | 10 | 5 | 68:48 | 20 | 55 |
| 2 |
|
OFC Oostzaan | 30 | 16 | 5 | 9 | 60:46 | 14 | 53 |
| 3 |
|
USV Hercules | 30 | 16 | 3 | 11 | 63:39 | 24 | 51 |
| 4 |
|
ADO '20 | 30 | 15 | 5 | 10 | 53:40 | 13 | 50 |
| 5 |
|
VV UNA | 30 | 15 | 4 | 11 | 53:44 | 9 | 49 |
| 6 |
|
RKSV Groene Ster | 30 | 14 | 7 | 9 | 44:42 | 2 | 49 |
| 7 |
|
OSS '20 | 30 | 14 | 6 | 10 | 54:42 | 12 | 47 |
| 8 |
|
Quick Den Haag | 30 | 14 | 4 | 12 | 47:37 | 10 | 46 |
| 9 |
|
HSC'21 | 30 | 13 | 4 | 13 | 53:42 | 11 | 43 |
| 10 |
|
VV Dongen | 30 | 11 | 10 | 9 | 49:41 | 8 | 43 |
| 11 |
|
Unitas Gorinchem | 30 | 12 | 5 | 13 | 38:52 | -14 | 41 |
| 12 |
|
Blauw Geel '38 | 30 | 12 | 4 | 14 | 50:50 | 0 | 40 |
| 13 |
|
RKVV DEM | 30 | 11 | 5 | 14 | 32:47 | -15 | 38 |
| 14 |
|
JOS Watergraafsmeer | 30 | 11 | 4 | 15 | 49:60 | -11 | 35 |
| 15 |
|
EVV | 30 | 7 | 10 | 13 | 32:53 | -21 | 31 |
| 16 |
|
VV Hoogland | 30 | 8 | 5 | 17 | 33:60 | -27 | 29 |
| 17 |
|
RKVV Westlandia | 30 | 7 | 7 | 16 | 34:51 | -17 | 28 |
| 18 |
|
HVV Hollandia | 30 | 8 | 4 | 18 | 31:49 | -18 | 28 |
| Promotion | |
| Relégation | |
| Relégation |
