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| 08.05.2022 | 14:00 | USV Hercules | - | Blauw Geel '38 | 7:1 (4:0) | |
| 14:00 | ADO '20 | - | HVV Hollandia | 1:0 (0:0) | ||
| 14:00 | Quick Den Haag | - | RKVV DEM | 3:0 (1:0) | ||
| 14:00 | RKVV Westlandia | - | VV Hoogland | 4:1 (2:0) | ||
| 14:00 | JOS Watergraafsmeer | - | VV Dongen | 3:2 (2:1) | ||
| 14:00 | Unitas Gorinchem | - | EVV | 3:0 (1:0) | ||
| 14:30 | RKSV Groene Ster | - | HSC'21 | 0:3 (0:2) | ||
| 14:30 | OSS '20 | - | VV Gemert | 0:0 (0:0) | ||
| 14:30 | VV UNA | - | OFC Oostzaan | 1:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 29 | 15 | 10 | 4 | 65:44 | 21 | 55 |
| 2 |
|
OFC Oostzaan | 29 | 16 | 4 | 9 | 60:46 | 14 | 52 |
| 3 |
|
RKSV Groene Ster | 29 | 14 | 7 | 8 | 43:39 | 4 | 49 |
| 4 |
|
USV Hercules | 29 | 15 | 3 | 11 | 60:38 | 22 | 48 |
| 5 |
|
ADO '20 | 29 | 14 | 5 | 10 | 51:39 | 12 | 47 |
| 6 |
|
VV UNA | 29 | 14 | 4 | 11 | 50:43 | 7 | 46 |
| 7 |
|
Quick Den Haag | 29 | 14 | 3 | 12 | 44:34 | 10 | 45 |
| 8 |
|
OSS '20 | 29 | 13 | 6 | 10 | 52:41 | 11 | 44 |
| 9 |
|
VV Dongen | 29 | 11 | 10 | 8 | 48:39 | 9 | 43 |
| 10 |
|
HSC'21 | 29 | 13 | 3 | 13 | 50:39 | 11 | 42 |
| 11 |
|
Unitas Gorinchem | 29 | 12 | 4 | 13 | 38:52 | -14 | 40 |
| 12 |
|
Blauw Geel '38 | 29 | 12 | 3 | 14 | 49:49 | 0 | 39 |
| 13 |
|
JOS Watergraafsmeer | 29 | 11 | 4 | 14 | 48:57 | -9 | 35 |
| 14 |
|
RKVV DEM | 29 | 10 | 5 | 14 | 29:45 | -16 | 35 |
| 15 |
|
VV Hoogland | 29 | 8 | 5 | 16 | 32:58 | -26 | 29 |
| 16 |
|
RKVV Westlandia | 29 | 7 | 7 | 15 | 32:48 | -16 | 28 |
| 17 |
|
EVV | 29 | 6 | 10 | 13 | 28:50 | -22 | 28 |
| 18 |
|
HVV Hollandia | 29 | 8 | 3 | 18 | 30:48 | -18 | 27 |
| Promotion | |
| Relégation | |
| Relégation |
