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| 06.04.2022 | 19:30 | Quick Den Haag | - | EVV | 5:0 (1:0) | |
| 19:30 | Blauw Geel '38 | - | VV Gemert | 2:5 (2:2) | ||
| 19:30 | HSC'21 | - | OFC Oostzaan | 1:1 (1:0) | ||
| 19:30 | RKSV Groene Ster | - | VV UNA | 2:1 (1:1) | ||
| 19:30 | OSS '20 | - | Unitas Gorinchem | 3:2 (1:0) | ||
| 20:00 | VV Hoogland | - | HVV Hollandia | 0:4 (0:1) | ||
| 20:00 | RKVV DEM | - | VV Dongen | 2:1 (1:1) | ||
| 20:00 | RKVV Westlandia | - | ADO '20 | 0:2 (0:0) | ||
| 20:15 | USV Hercules | - | JOS Watergraafsmeer | 3:0 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 22 | 13 | 8 | 1 | 53:32 | 21 | 47 |
| 2 |
|
OFC Oostzaan | 22 | 14 | 3 | 5 | 47:32 | 15 | 45 |
| 3 |
|
RKSV Groene Ster | 22 | 11 | 7 | 4 | 34:27 | 7 | 40 |
| 4 |
|
ADO '20 | 22 | 12 | 1 | 9 | 38:29 | 9 | 37 |
| 5 |
|
USV Hercules | 22 | 11 | 3 | 8 | 43:30 | 13 | 36 |
| 6 |
|
OSS '20 | 22 | 11 | 3 | 8 | 43:33 | 10 | 35 |
| 7 |
|
VV Dongen | 22 | 9 | 8 | 5 | 35:26 | 9 | 35 |
| 8 |
|
VV UNA | 22 | 10 | 4 | 8 | 38:36 | 2 | 34 |
| 9 |
|
Quick Den Haag | 22 | 10 | 2 | 10 | 30:26 | 4 | 32 |
| 10 |
|
Unitas Gorinchem | 22 | 9 | 3 | 10 | 29:41 | -12 | 30 |
| 11 |
|
JOS Watergraafsmeer | 22 | 9 | 3 | 10 | 39:42 | -3 | 28 |
| 12 |
|
HSC'21 | 22 | 8 | 3 | 11 | 38:31 | 7 | 27 |
| 13 |
|
Blauw Geel '38 | 22 | 7 | 3 | 12 | 37:39 | -2 | 24 |
| 14 |
|
HVV Hollandia | 22 | 7 | 3 | 12 | 24:33 | -9 | 24 |
| 15 |
|
EVV | 22 | 4 | 9 | 9 | 18:34 | -16 | 21 |
| 16 |
|
RKVV DEM | 22 | 5 | 5 | 12 | 19:39 | -20 | 20 |
| 17 |
|
VV Hoogland | 22 | 5 | 4 | 13 | 22:47 | -25 | 19 |
| 18 |
|
RKVV Westlandia | 22 | 4 | 6 | 12 | 21:31 | -10 | 18 |
| Promotion | |
| Relégation | |
| Relégation |
