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| 27.03.2022 | 14:00 | USV Hercules | - | VV Dongen | 1:3 (0:0) | |
| 14:00 | Quick Den Haag | - | VV Gemert | 1:3 (0:1) | ||
| 14:00 | Blauw Geel '38 | - | VV Hoogland | 5:1 (3:0) | ||
| 14:00 | RKVV DEM | - | EVV | 2:2 (1:0) | ||
| 14:00 | RKVV Westlandia | - | OFC Oostzaan | 0:1 (0:1) | ||
| 14:30 | HSC'21 | - | Unitas Gorinchem | 4:0 (1:0) | ||
| 14:30 | RKSV Groene Ster | - | HVV Hollandia | 3:1 (1:0) | ||
| 14:30 | OSS '20 | - | JOS Watergraafsmeer | 6:0 (3:0) | ||
| 14:30 | VV UNA | - | ADO '20 | 0:2 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 20 | 12 | 7 | 1 | 45:27 | 18 | 43 |
| 2 |
|
OFC Oostzaan | 20 | 14 | 1 | 5 | 44:29 | 15 | 43 |
| 3 |
|
RKSV Groene Ster | 20 | 10 | 6 | 4 | 30:24 | 6 | 36 |
| 4 |
|
ADO '20 | 20 | 11 | 1 | 8 | 36:28 | 8 | 34 |
| 5 |
|
VV UNA | 20 | 10 | 4 | 6 | 36:29 | 7 | 34 |
| 6 |
|
OSS '20 | 20 | 10 | 3 | 7 | 39:28 | 11 | 32 |
| 7 |
|
VV Dongen | 20 | 8 | 8 | 4 | 32:24 | 8 | 32 |
| 8 |
|
USV Hercules | 20 | 9 | 3 | 8 | 35:29 | 6 | 30 |
| 9 |
|
Unitas Gorinchem | 20 | 9 | 2 | 9 | 27:38 | -11 | 29 |
| 10 |
|
HSC'21 | 20 | 8 | 2 | 10 | 37:29 | 8 | 26 |
| 11 |
|
Quick Den Haag | 20 | 8 | 2 | 10 | 24:26 | -2 | 26 |
| 12 |
|
JOS Watergraafsmeer | 20 | 8 | 3 | 9 | 38:39 | -1 | 25 |
| 13 |
|
Blauw Geel '38 | 20 | 7 | 2 | 11 | 35:34 | 1 | 23 |
| 14 |
|
VV Hoogland | 20 | 5 | 4 | 11 | 22:41 | -19 | 19 |
| 15 |
|
RKVV Westlandia | 20 | 4 | 6 | 10 | 21:27 | -6 | 18 |
| 16 |
|
EVV | 20 | 3 | 9 | 8 | 16:29 | -13 | 18 |
| 17 |
|
HVV Hollandia | 20 | 5 | 3 | 12 | 17:32 | -15 | 18 |
| 18 |
|
RKVV DEM | 20 | 4 | 4 | 12 | 14:35 | -21 | 16 |
| Promotion | |
| Relégation | |
| Relégation |
