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| 13.03.2022 | 14:00 | USV Hercules | - | VV Gemert | 1:2 (0:2) | |
| 14:00 | VV Hoogland | - | OFC Oostzaan | 4:1 (1:1) | ||
| 14:00 | Quick Den Haag | - | Unitas Gorinchem | 3:0 (0:0) | ||
| 14:00 | Blauw Geel '38 | - | EVV | 0:1 (0:0) | ||
| 14:00 | RKVV DEM | - | JOS Watergraafsmeer | 0:1 (0:0) | ||
| 14:30 | HSC'21 | - | VV Dongen | 4:3 (1:0) | ||
| 14:30 | RKSV Groene Ster | - | ADO '20 | 1:0 (0:0) | ||
| 14:30 | OSS '20 | - | VV UNA | 1:1 (1:0) | ||
| 30.03.2022 | 20:00 | RKVV Westlandia | - | HVV Hollandia | 3:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 18 | 13 | 1 | 4 | 42:27 | 15 | 40 |
| 2 |
|
VV Gemert | 18 | 10 | 7 | 1 | 41:26 | 15 | 37 |
| 3 |
|
RKSV Groene Ster | 18 | 9 | 6 | 3 | 26:21 | 5 | 33 |
| 4 |
|
VV UNA | 18 | 9 | 4 | 5 | 32:26 | 6 | 31 |
| 5 |
|
Unitas Gorinchem | 18 | 9 | 2 | 7 | 26:30 | -4 | 29 |
| 6 |
|
ADO '20 | 18 | 9 | 1 | 8 | 32:27 | 5 | 28 |
| 7 |
|
USV Hercules | 18 | 8 | 3 | 7 | 32:25 | 7 | 27 |
| 8 |
|
VV Dongen | 18 | 6 | 8 | 4 | 27:22 | 5 | 26 |
| 9 |
|
OSS '20 | 18 | 8 | 3 | 7 | 30:27 | 3 | 26 |
| 10 |
|
JOS Watergraafsmeer | 18 | 8 | 3 | 7 | 37:31 | 6 | 25 |
| 11 |
|
Quick Den Haag | 18 | 7 | 2 | 9 | 21:22 | -1 | 23 |
| 12 |
|
HSC'21 | 18 | 6 | 2 | 10 | 29:29 | 0 | 20 |
| 13 |
|
Blauw Geel '38 | 18 | 6 | 2 | 10 | 29:31 | -2 | 20 |
| 14 |
|
VV Hoogland | 18 | 5 | 4 | 9 | 21:35 | -14 | 19 |
| 15 |
|
RKVV Westlandia | 18 | 4 | 6 | 8 | 21:25 | -4 | 18 |
| 16 |
|
HVV Hollandia | 18 | 5 | 3 | 10 | 16:25 | -9 | 18 |
| 17 |
|
EVV | 18 | 3 | 8 | 7 | 13:24 | -11 | 17 |
| 18 |
|
RKVV DEM | 18 | 3 | 3 | 12 | 11:33 | -22 | 12 |
| Promotion | |
| Relégation | |
| Relégation |
