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| 23.04.2022 | 14:30 | VVOG Harderwijk | - | VV GOES | 3:4 (1:1) | |
| 14:30 | HSV Hoek | - | VV DOVO Veenendaal | 2:3 (1:2) | ||
| 14:30 | Excelsior '31 | - | DVS'33 | 3:1 (1:0) | ||
| 14:30 | Harkemase Boys | - | Ter Leede | 5:1 (2:0) | ||
| 14:30 | ACV Assen | - | BVV Barendrecht | 4:1 (1:0) | ||
| 14:30 | ODIN '59 | - | VV Staphorst | 4:1 (1:0) | ||
| 14:30 | SteDoCo | - | FC Lisse | 0:1 (0:0) | ||
| 15:00 | Sparta Nijkerk | - | Sportlust '46 | 0:1 (0:0) | ||
| 18:00 | VV Sint Bavo | - | AFC Ajax Zaterdag | 2:0 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 27 | 16 | 5 | 6 | 52:32 | 20 | 53 |
| 2 |
|
Sparta Nijkerk | 27 | 14 | 7 | 6 | 45:26 | 19 | 49 |
| 3 |
|
Sportlust '46 | 27 | 14 | 6 | 7 | 48:33 | 15 | 48 |
| 4 |
|
Excelsior '31 | 27 | 13 | 7 | 7 | 47:35 | 12 | 46 |
| 5 |
|
HSV Hoek | 27 | 12 | 7 | 8 | 43:37 | 6 | 43 |
| 6 |
|
BVV Barendrecht | 27 | 10 | 10 | 7 | 54:44 | 10 | 40 |
| 7 |
|
DVS'33 | 27 | 12 | 3 | 12 | 45:35 | 10 | 39 |
| 8 |
|
VV Staphorst | 27 | 11 | 6 | 10 | 41:40 | 1 | 39 |
| 9 |
|
ACV Assen | 27 | 10 | 8 | 9 | 36:31 | 5 | 38 |
| 10 |
|
SteDoCo | 27 | 11 | 5 | 11 | 44:41 | 3 | 38 |
| 11 |
|
Harkemase Boys | 27 | 8 | 10 | 9 | 51:48 | 3 | 34 |
| 12 |
|
Ter Leede | 27 | 10 | 4 | 13 | 34:49 | -15 | 34 |
| 13 |
|
ODIN '59 | 27 | 8 | 7 | 12 | 40:53 | -13 | 31 |
| 14 |
|
VVOG Harderwijk | 27 | 8 | 7 | 12 | 50:64 | -14 | 31 |
| 15 |
|
VV Sint Bavo | 27 | 8 | 6 | 13 | 42:48 | -6 | 30 |
| 16 |
|
AFC Ajax Zaterdag | 27 | 8 | 5 | 14 | 29:44 | -15 | 29 |
| 17 |
|
VV GOES | 27 | 5 | 9 | 13 | 39:60 | -21 | 24 |
| 18 |
|
VV DOVO Veenendaal | 27 | 5 | 8 | 14 | 28:48 | -20 | 23 |
| Promotion | |
| Relégation | |
| Relégation |
