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| 18.04.2022 | 14:30 | AFC Ajax Zaterdag | - | Excelsior '31 | 0:1 (0:1) | |
| 14:30 | VV Staphorst | - | BVV Barendrecht | 4:1 (3:1) | ||
| 14:30 | FC Lisse | - | ODIN '59 | 3:3 (3:0) | ||
| 14:30 | VV GOES | - | Harkemase Boys | 3:3 (1:1) | ||
| 14:30 | DVS'33 | - | SteDoCo | 3:1 (1:0) | ||
| 15:00 | Sparta Nijkerk | - | ACV Assen | 2:2 (0:2) | ||
| 15:00 | Ter Leede | - | HSV Hoek | 2:3 (1:1) | ||
| 15:00 | VV DOVO Veenendaal | - | VVOG Harderwijk | 1:2 (0:1) | ||
| 16:30 | Sportlust '46 | - | VV Sint Bavo | 1:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 26 | 15 | 5 | 6 | 51:32 | 19 | 50 |
| 2 |
|
Sparta Nijkerk | 26 | 14 | 7 | 5 | 45:25 | 20 | 49 |
| 3 |
|
Sportlust '46 | 26 | 13 | 6 | 7 | 47:33 | 14 | 45 |
| 4 |
|
Excelsior '31 | 26 | 12 | 7 | 7 | 44:34 | 10 | 43 |
| 5 |
|
HSV Hoek | 26 | 12 | 7 | 7 | 41:34 | 7 | 43 |
| 6 |
|
BVV Barendrecht | 26 | 10 | 10 | 6 | 53:40 | 13 | 40 |
| 7 |
|
DVS'33 | 26 | 12 | 3 | 11 | 44:32 | 12 | 39 |
| 8 |
|
VV Staphorst | 26 | 11 | 6 | 9 | 40:36 | 4 | 39 |
| 9 |
|
SteDoCo | 26 | 11 | 5 | 10 | 44:40 | 4 | 38 |
| 10 |
|
ACV Assen | 26 | 9 | 8 | 9 | 32:30 | 2 | 35 |
| 11 |
|
Ter Leede | 26 | 10 | 4 | 12 | 33:44 | -11 | 34 |
| 12 |
|
Harkemase Boys | 26 | 7 | 10 | 9 | 46:47 | -1 | 31 |
| 13 |
|
VVOG Harderwijk | 26 | 8 | 7 | 11 | 47:60 | -13 | 31 |
| 14 |
|
AFC Ajax Zaterdag | 26 | 8 | 5 | 13 | 29:42 | -13 | 29 |
| 15 |
|
ODIN '59 | 26 | 7 | 7 | 12 | 36:52 | -16 | 28 |
| 16 |
|
VV Sint Bavo | 26 | 7 | 6 | 13 | 40:48 | -8 | 27 |
| 17 |
|
VV GOES | 26 | 4 | 9 | 13 | 35:57 | -22 | 21 |
| 18 |
|
VV DOVO Veenendaal | 26 | 4 | 8 | 14 | 25:46 | -21 | 20 |
| Promotion | |
| Relégation | |
| Relégation |
