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| 05.04.2022 | 19:15 | VV GOES | - | VV Staphorst | 0:1 (0:0) | |
| 20:00 | VVOG Harderwijk | - | VV Sint Bavo | 4:3 (2:1) | ||
| 20:00 | AFC Ajax Zaterdag | - | Sportlust '46 | 2:1 (0:1) | ||
| 20:00 | FC Lisse | - | DVS'33 | 1:0 (1:0) | ||
| 20:00 | Excelsior '31 | - | BVV Barendrecht | 0:0 (0:0) | ||
| 20:00 | Harkemase Boys | - | SteDoCo | 1:2 (0:0) | ||
| 20:00 | ACV Assen | - | VV DOVO Veenendaal | 3:0 (2:0) | ||
| 20:00 | ODIN '59 | - | HSV Hoek | 0:2 (0:1) | ||
| 20:00 | Sparta Nijkerk | - | Ter Leede | 3:0 (3:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sparta Nijkerk | 22 | 14 | 5 | 3 | 41:18 | 23 | 47 |
| 2 |
|
FC Lisse | 22 | 14 | 3 | 5 | 45:23 | 22 | 45 |
| 3 |
|
Sportlust '46 | 22 | 11 | 5 | 6 | 42:31 | 11 | 38 |
| 4 |
|
HSV Hoek | 22 | 10 | 6 | 6 | 34:26 | 8 | 36 |
| 5 |
|
Excelsior '31 | 22 | 10 | 5 | 7 | 38:30 | 8 | 35 |
| 6 |
|
BVV Barendrecht | 22 | 8 | 10 | 4 | 42:30 | 12 | 34 |
| 7 |
|
VV Staphorst | 22 | 9 | 5 | 8 | 33:32 | 1 | 32 |
| 8 |
|
Ter Leede | 22 | 9 | 4 | 9 | 27:35 | -8 | 31 |
| 9 |
|
DVS'33 | 22 | 9 | 3 | 10 | 32:28 | 4 | 30 |
| 10 |
|
ACV Assen | 22 | 8 | 6 | 8 | 27:25 | 2 | 30 |
| 11 |
|
SteDoCo | 22 | 8 | 5 | 9 | 36:35 | 1 | 29 |
| 12 |
|
AFC Ajax Zaterdag | 22 | 8 | 3 | 11 | 26:37 | -11 | 27 |
| 13 |
|
Harkemase Boys | 22 | 6 | 8 | 8 | 40:39 | 1 | 26 |
| 14 |
|
ODIN '59 | 22 | 7 | 5 | 10 | 31:44 | -13 | 26 |
| 15 |
|
VVOG Harderwijk | 22 | 6 | 6 | 10 | 41:55 | -14 | 24 |
| 16 |
|
VV Sint Bavo | 22 | 5 | 5 | 12 | 30:41 | -11 | 20 |
| 17 |
|
VV DOVO Veenendaal | 22 | 4 | 7 | 11 | 21:37 | -16 | 19 |
| 18 |
|
VV GOES | 22 | 3 | 7 | 12 | 26:46 | -20 | 16 |
| Promotion | |
| Relégation | |
| Relégation |
