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| 26.03.2022 | 14:30 | VVOG Harderwijk | - | VV Staphorst | 2:1 (1:1) | |
| 14:30 | FC Lisse | - | AFC Ajax Zaterdag | 2:0 (1:0) | ||
| 14:30 | Excelsior '31 | - | VV DOVO Veenendaal | 1:0 (0:0) | ||
| 14:30 | Harkemase Boys | - | Sportlust '46 | 0:1 (0:1) | ||
| 14:30 | ACV Assen | - | VV Sint Bavo | 1:1 (1:1) | ||
| 14:30 | ODIN '59 | - | BVV Barendrecht | 2:2 (1:0) | ||
| 15:00 | Sparta Nijkerk | - | DVS'33 | 2:0 (1:0) | ||
| 12.04.2022 | 20:00 | SteDoCo | - | HSV Hoek | 3:3 (2:2) | |
| 20:30 | VV GOES | - | Ter Leede | 0:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sparta Nijkerk | 20 | 13 | 4 | 3 | 38:18 | 20 | 43 |
| 2 |
|
FC Lisse | 20 | 13 | 2 | 5 | 44:23 | 21 | 41 |
| 3 |
|
Sportlust '46 | 20 | 11 | 4 | 5 | 41:29 | 12 | 37 |
| 4 |
|
Excelsior '31 | 20 | 10 | 4 | 6 | 36:26 | 10 | 34 |
| 5 |
|
BVV Barendrecht | 20 | 8 | 8 | 4 | 42:30 | 12 | 32 |
| 6 |
|
HSV Hoek | 20 | 9 | 5 | 6 | 32:26 | 6 | 32 |
| 7 |
|
Ter Leede | 20 | 8 | 4 | 8 | 25:32 | -7 | 28 |
| 8 |
|
DVS'33 | 20 | 8 | 3 | 9 | 27:26 | 1 | 27 |
| 9 |
|
SteDoCo | 20 | 7 | 5 | 8 | 33:30 | 3 | 26 |
| 10 |
|
VV Staphorst | 20 | 7 | 5 | 8 | 31:32 | -1 | 26 |
| 11 |
|
ACV Assen | 20 | 7 | 5 | 8 | 24:25 | -1 | 26 |
| 12 |
|
ODIN '59 | 20 | 7 | 5 | 8 | 31:40 | -9 | 26 |
| 13 |
|
Harkemase Boys | 20 | 6 | 7 | 7 | 39:37 | 2 | 25 |
| 14 |
|
AFC Ajax Zaterdag | 20 | 7 | 3 | 10 | 24:35 | -11 | 24 |
| 15 |
|
VV DOVO Veenendaal | 20 | 4 | 6 | 10 | 21:34 | -13 | 18 |
| 16 |
|
VVOG Harderwijk | 20 | 4 | 6 | 10 | 33:51 | -18 | 18 |
| 17 |
|
VV Sint Bavo | 20 | 4 | 5 | 11 | 23:35 | -12 | 17 |
| 18 |
|
VV GOES | 20 | 3 | 7 | 10 | 25:40 | -15 | 16 |
| Promotion | |
| Relégation | |
| Relégation |
