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| 04.09.2022 | 16:00 | FK AP Brera Strumica | - | FC Struga | 0:3 (0:1) | |
| 16:00 | FK Bregalnica Štip | - | KF Shkupi | 2:0 (0:0) | ||
| 16:00 | FK Skopje | - | FK Pobeda Junior | 1:0 (1:0) | ||
| 16:00 | KF Shkëndija 79 | - | Makedonija GP | 1:1 (0:0) | ||
| 16:00 | Sileks Kratovo | - | GFK Tikvesh | 3:2 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Struga | 6 | 6 | 0 | 0 | 13:2 | 11 | 18 |
| 2 |
|
Sileks Kratovo | 6 | 3 | 2 | 1 | 11:7 | 4 | 11 |
| 3 |
|
KF Shkëndija 79 | 6 | 3 | 2 | 1 | 8:5 | 3 | 11 |
| 4 |
|
FK Bregalnica Štip | 5 | 3 | 1 | 1 | 6:3 | 3 | 10 |
| 5 |
|
FK AP Brera Strumica | 6 | 2 | 1 | 3 | 10:7 | 3 | 7 |
| 6 |
|
KF Shkupi | 5 | 2 | 1 | 2 | 6:7 | -1 | 7 |
| 7 |
|
GFK Tikvesh | 6 | 2 | 1 | 3 | 8:10 | -2 | 7 |
| 8 |
|
Makedonija GP | 5 | 1 | 2 | 2 | 7:6 | 1 | 5 |
| 9 |
|
FK Rabotnički | 5 | 1 | 1 | 3 | 4:10 | -6 | 4 |
| 10 |
|
FK Skopje | 5 | 1 | 0 | 4 | 2:10 | -8 | 3 |
| 11 |
|
FK Pobeda Junior | 5 | 0 | 1 | 4 | 2:10 | -8 | 1 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
