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| 19.09.2021 | 15:00 | FK Bregalnica Štip | - | GFK Tikvesh | 2:0 (0:0) | |
| 15:00 | FK Pelister | - | FK AP Brera Strumica | 0:0 (0:0) | ||
| 15:00 | KF Shkupi | - | FK Borec | 3:0 (2:0) | ||
| 15:00 | FK Skopje | - | KF Shkëndija 79 | 0:2 (0:1) | ||
| 15:00 | Makedonija GP | - | FK Rabotnički | 0:2 (0:0) | ||
| 15:00 | FK Renova | - | FC Struga | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 7 | 4 | 2 | 1 | 13:5 | 8 | 14 |
| 2 |
|
FK AP Brera Strumica | 7 | 4 | 2 | 1 | 13:6 | 7 | 14 |
| 3 |
|
FK Renova | 7 | 4 | 2 | 1 | 10:5 | 5 | 14 |
| 4 |
|
FK Rabotnički | 7 | 4 | 2 | 1 | 8:4 | 4 | 14 |
| 5 |
|
FC Struga | 7 | 3 | 3 | 1 | 8:5 | 3 | 12 |
| 6 |
|
KF Shkëndija 79 | 7 | 2 | 4 | 1 | 12:7 | 5 | 10 |
| 7 |
|
FK Bregalnica Štip | 7 | 2 | 4 | 1 | 9:8 | 1 | 10 |
| 8 |
|
Makedonija GP | 7 | 3 | 0 | 4 | 10:15 | -5 | 9 |
| 9 |
|
FK Borec | 7 | 2 | 1 | 4 | 7:12 | -5 | 7 |
| 10 |
|
FK Skopje | 7 | 1 | 2 | 4 | 4:13 | -9 | 5 |
| 11 |
|
FK Pelister | 7 | 0 | 2 | 5 | 3:9 | -6 | 2 |
| 12 |
|
GFK Tikvesh | 7 | 0 | 2 | 5 | 3:11 | -8 | 2 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
