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| 28.08.2021 | 16:00 | FK Bregalnica Štip | - | FK AP Brera Strumica | 3:2 (0:1) | |
| 16:00 | FK Pelister | - | KF Shkëndija 79 | 2:2 (1:1) | ||
| 16:00 | KF Shkupi | - | FK Skopje | 4:1 (1:0) | ||
| 16:00 | Makedonija GP | - | FK Borec | 3:2 (1:1) | ||
| 16:00 | FK Renova | - | FK Rabotnički | 1:1 (1:1) | ||
| 16:00 | GFK Tikvesh | - | FC Struga | 1:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 5 | 3 | 1 | 1 | 10:5 | 5 | 10 |
| 2 |
|
FK AP Brera Strumica | 5 | 3 | 1 | 1 | 9:5 | 4 | 10 |
| 3 |
|
FC Struga | 5 | 2 | 3 | 0 | 7:4 | 3 | 9 |
| 4 |
|
Makedonija GP | 5 | 3 | 0 | 2 | 9:9 | 0 | 9 |
| 5 |
|
FK Renova | 5 | 2 | 2 | 1 | 7:5 | 2 | 8 |
| 6 |
|
FK Rabotnički | 5 | 2 | 2 | 1 | 4:4 | 0 | 8 |
| 7 |
|
FK Bregalnica Štip | 5 | 1 | 4 | 0 | 7:6 | 1 | 7 |
| 8 |
|
KF Shkëndija 79 | 5 | 1 | 3 | 1 | 10:7 | 3 | 6 |
| 9 |
|
FK Skopje | 5 | 1 | 2 | 2 | 4:10 | -6 | 5 |
| 10 |
|
FK Borec | 5 | 1 | 1 | 3 | 5:8 | -3 | 4 |
| 11 |
|
GFK Tikvesh | 5 | 0 | 2 | 3 | 3:7 | -4 | 2 |
| 12 |
|
FK Pelister | 5 | 0 | 1 | 4 | 2:7 | -5 | 1 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
