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| 18.08.2021 | 17:00 | FK Bregalnica Štip | - | KF Shkëndija 79 | 3:3 (1:0) | |
| 17:00 | FK Pelister | - | KF Shkupi | 0:2 (0:2) | ||
| 17:00 | FK Rabotnički | - | FC Struga | 0:0 (0:0) | ||
| 17:00 | Makedonija GP | - | FK Skopje | 5:1 (2:1) | ||
| 17:00 | FK Renova | - | FK Borec | 2:0 (1:0) | ||
| 17:00 | GFK Tikvesh | - | FK AP Brera Strumica | 0:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK AP Brera Strumica | 3 | 2 | 1 | 0 | 5:1 | 4 | 7 |
| 2 |
|
KF Shkupi | 3 | 2 | 1 | 0 | 4:0 | 4 | 7 |
| 3 |
|
FK Renova | 3 | 2 | 1 | 0 | 5:2 | 3 | 7 |
| 4 |
|
Makedonija GP | 3 | 2 | 0 | 1 | 6:3 | 3 | 6 |
| 5 |
|
FC Struga | 3 | 1 | 2 | 0 | 2:1 | 1 | 5 |
| 6 |
|
FK Rabotnički | 3 | 1 | 1 | 1 | 1:2 | -1 | 4 |
| 7 |
|
FK Bregalnica Štip | 3 | 0 | 3 | 0 | 3:3 | 0 | 3 |
| 8 |
|
FK Borec | 3 | 1 | 0 | 2 | 2:4 | -2 | 3 |
| 9 |
|
KF Shkëndija 79 | 3 | 0 | 2 | 1 | 4:5 | -1 | 2 |
| 10 |
|
FK Skopje | 3 | 0 | 2 | 1 | 2:6 | -4 | 2 |
| 11 |
|
GFK Tikvesh | 3 | 0 | 1 | 2 | 1:4 | -3 | 1 |
| 12 |
|
FK Pelister | 3 | 0 | 0 | 3 | 0:4 | -4 | 0 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
