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| 02.04.2022 | 15:00 | FK Rabotnički | - | FC Struga | 1:3 (0:1) | |
| 03.04.2022 | 15:00 | KF Shkupi | - | GFK Tikvesh | 1:0 (0:0) | |
| 15:00 | FK AP Brera Strumica | - | FK Skopje | 1:2 (1:0) | ||
| 15:00 | KF Shkëndija 79 | - | FK Borec | 0:0 (0:0) | ||
| 15:00 | Makedonija GP | - | FK Pelister | 2:0 (0:0) | ||
| 15:00 | FK Bregalnica Štip | - | FK Renova | 2:2 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 25 | 19 | 4 | 2 | 55:15 | 40 | 61 |
| 2 |
|
KF Shkëndija 79 | 25 | 13 | 9 | 3 | 39:18 | 21 | 48 |
| 3 |
|
FK AP Brera Strumica | 25 | 14 | 6 | 5 | 43:23 | 20 | 48 |
| 4 |
|
Makedonija GP | 25 | 14 | 4 | 7 | 38:34 | 4 | 46 |
| 5 |
|
FK Renova | 25 | 9 | 10 | 6 | 32:22 | 10 | 37 |
| 6 |
|
FK Bregalnica Štip | 25 | 10 | 7 | 8 | 37:35 | 2 | 37 |
| 7 |
|
FC Struga | 25 | 8 | 9 | 8 | 22:26 | -4 | 33 |
| 8 |
|
FK Rabotnički | 25 | 9 | 4 | 12 | 20:28 | -8 | 31 |
| 9 |
|
FK Skopje | 25 | 6 | 7 | 12 | 17:36 | -19 | 25 |
| 10 |
|
GFK Tikvesh | 25 | 5 | 6 | 14 | 24:32 | -8 | 21 |
| 11 |
|
FK Borec | 25 | 3 | 5 | 17 | 17:48 | -31 | 14 |
| 12 |
|
FK Pelister | 25 | 1 | 7 | 17 | 10:37 | -27 | 10 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
