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| 12.03.2022 | 15:00 | KF Shkupi | - | FK Rabotnički | 2:0 (0:0) | |
| 13.03.2022 | 15:00 | FK AP Brera Strumica | - | FC Struga | 1:0 (1:0) | |
| 15:00 | KF Shkëndija 79 | - | GFK Tikvesh | 2:1 (1:0) | ||
| 15:00 | Makedonija GP | - | FK Skopje | 1:1 (1:1) | ||
| 15:00 | FK Bregalnica Štip | - | FK Borec | 3:0 (1:0) | ||
| 14.03.2022 | 15:00 | FK Renova | - | FK Pelister | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 23 | 17 | 4 | 2 | 51:14 | 37 | 55 |
| 2 |
|
FK AP Brera Strumica | 23 | 13 | 6 | 4 | 40:20 | 20 | 45 |
| 3 |
|
KF Shkëndija 79 | 23 | 12 | 8 | 3 | 37:18 | 19 | 44 |
| 4 |
|
Makedonija GP | 23 | 12 | 4 | 7 | 35:34 | 1 | 40 |
| 5 |
|
FK Bregalnica Štip | 23 | 10 | 6 | 7 | 35:31 | 4 | 36 |
| 6 |
|
FK Renova | 23 | 8 | 9 | 6 | 28:19 | 9 | 33 |
| 7 |
|
FK Rabotnički | 23 | 9 | 4 | 10 | 18:23 | -5 | 31 |
| 8 |
|
FC Struga | 23 | 7 | 9 | 7 | 18:22 | -4 | 30 |
| 9 |
|
FK Skopje | 23 | 5 | 7 | 11 | 15:33 | -18 | 22 |
| 10 |
|
GFK Tikvesh | 23 | 5 | 6 | 12 | 23:29 | -6 | 21 |
| 11 |
|
FK Borec | 23 | 3 | 4 | 16 | 17:47 | -30 | 13 |
| 12 |
|
FK Pelister | 23 | 0 | 7 | 16 | 8:35 | -27 | 7 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
