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| 05.03.2022 | 14:00 | GFK Tikvesh | - | FK Skopje | 3:0 (1:0) | |
| 09.03.2022 | 14:00 | FK AP Brera Strumica | - | FK Borec | 5:0 (3:0) | |
| 14:00 | FK Bregalnica Štip | - | FK Pelister | 2:1 (1:0) | ||
| 14:00 | FK Rabotnički | - | KF Shkëndija 79 | 2:1 (1:1) | ||
| 14:00 | FK Renova | - | KF Shkupi | 0:0 (0:0) | ||
| 14:00 | FC Struga | - | Makedonija GP | 1:3 (0:3) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 22 | 16 | 4 | 2 | 49:14 | 35 | 52 |
| 2 |
|
FK AP Brera Strumica | 22 | 12 | 6 | 4 | 39:20 | 19 | 42 |
| 3 |
|
KF Shkëndija 79 | 22 | 11 | 8 | 3 | 35:17 | 18 | 41 |
| 4 |
|
Makedonija GP | 22 | 12 | 3 | 7 | 34:33 | 1 | 39 |
| 5 |
|
FK Bregalnica Štip | 22 | 9 | 6 | 7 | 32:31 | 1 | 33 |
| 6 |
|
FK Renova | 22 | 8 | 8 | 6 | 28:19 | 9 | 32 |
| 7 |
|
FK Rabotnički | 22 | 9 | 4 | 9 | 18:21 | -3 | 31 |
| 8 |
|
FC Struga | 22 | 7 | 9 | 6 | 18:21 | -3 | 30 |
| 9 |
|
GFK Tikvesh | 22 | 5 | 6 | 11 | 22:27 | -5 | 21 |
| 10 |
|
FK Skopje | 22 | 5 | 6 | 11 | 14:32 | -18 | 21 |
| 11 |
|
FK Borec | 22 | 3 | 4 | 15 | 17:44 | -27 | 13 |
| 12 |
|
FK Pelister | 22 | 0 | 6 | 16 | 8:35 | -27 | 6 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
