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| 04.12.2021 | 13:00 | FK Rabotnički | - | FK Renova | 0:0 (0:0) | |
| 05.12.2021 | 13:00 | FK AP Brera Strumica | - | FK Bregalnica Štip | 0:0 (0:0) | |
| 13:00 | FK Borec | - | Makedonija GP | 1:1 (1:0) | ||
| 13:00 | FK Skopje | - | KF Shkupi | 1:3 (1:1) | ||
| 13:00 | KF Shkëndija 79 | - | FK Pelister | 2:1 (0:1) | ||
| 13:00 | FC Struga | - | GFK Tikvesh | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 16 | 12 | 2 | 2 | 39:10 | 29 | 38 |
| 2 |
|
FK AP Brera Strumica | 16 | 9 | 5 | 2 | 26:14 | 12 | 32 |
| 3 |
|
KF Shkëndija 79 | 16 | 8 | 6 | 2 | 26:13 | 13 | 30 |
| 4 |
|
FK Renova | 16 | 7 | 5 | 4 | 24:14 | 10 | 26 |
| 5 |
|
FK Bregalnica Štip | 16 | 7 | 5 | 4 | 23:22 | 1 | 26 |
| 6 |
|
FC Struga | 16 | 5 | 8 | 3 | 13:13 | 0 | 23 |
| 7 |
|
Makedonija GP | 16 | 6 | 3 | 7 | 21:29 | -8 | 21 |
| 8 |
|
FK Rabotnički | 16 | 5 | 4 | 7 | 10:16 | -6 | 19 |
| 9 |
|
FK Skopje | 16 | 4 | 5 | 7 | 12:21 | -9 | 17 |
| 10 |
|
GFK Tikvesh | 16 | 3 | 5 | 8 | 14:19 | -5 | 14 |
| 11 |
|
FK Borec | 16 | 2 | 3 | 11 | 13:30 | -17 | 9 |
| 12 |
|
FK Pelister | 16 | 0 | 5 | 11 | 5:25 | -20 | 5 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
