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| 27.11.2021 | 13:00 | FK Renova | - | FK AP Brera Strumica | 1:2 (0:1) | |
| 28.11.2021 | 13:00 | FK Bregalnica Štip | - | FK Borec | 2:1 (1:1) | |
| 13:00 | FK Pelister | - | FK Skopje | 0:0 (0:0) | ||
| 13:00 | KF Shkupi | - | FC Struga | 4:0 (0:0) | ||
| 13:00 | Makedonija GP | - | KF Shkëndija 79 | 1:2 (0:1) | ||
| 13:00 | GFK Tikvesh | - | FK Rabotnički | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 15 | 11 | 2 | 2 | 36:9 | 27 | 35 |
| 2 |
|
FK AP Brera Strumica | 15 | 9 | 4 | 2 | 26:14 | 12 | 31 |
| 3 |
|
KF Shkëndija 79 | 15 | 7 | 6 | 2 | 24:12 | 12 | 27 |
| 4 |
|
FK Renova | 15 | 7 | 4 | 4 | 24:14 | 10 | 25 |
| 5 |
|
FK Bregalnica Štip | 15 | 7 | 4 | 4 | 23:22 | 1 | 25 |
| 6 |
|
FC Struga | 15 | 5 | 7 | 3 | 13:13 | 0 | 22 |
| 7 |
|
Makedonija GP | 15 | 6 | 2 | 7 | 20:28 | -8 | 20 |
| 8 |
|
FK Rabotnički | 15 | 5 | 3 | 7 | 10:16 | -6 | 18 |
| 9 |
|
FK Skopje | 15 | 4 | 5 | 6 | 11:18 | -7 | 17 |
| 10 |
|
GFK Tikvesh | 15 | 3 | 4 | 8 | 14:19 | -5 | 13 |
| 11 |
|
FK Borec | 15 | 2 | 2 | 11 | 12:29 | -17 | 8 |
| 12 |
|
FK Pelister | 15 | 0 | 5 | 10 | 4:23 | -19 | 5 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
