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| 06.11.2021 | 13:00 | FK Bregalnica Štip | - | FK Skopje | 2:1 (1:0) | |
| 13:00 | FK Pelister | - | FC Struga | 0:1 (0:1) | ||
| 13:00 | FK Rabotnički | - | FK AP Brera Strumica | 0:3 (0:3) | ||
| 13:00 | Makedonija GP | - | KF Shkupi | 2:1 (0:0) | ||
| 13:00 | FK Renova | - | KF Shkëndija 79 | 0:1 (0:1) | ||
| 13:00 | GFK Tikvesh | - | FK Borec | 2:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 13 | 9 | 2 | 2 | 27:9 | 18 | 29 |
| 2 |
|
FK AP Brera Strumica | 13 | 7 | 4 | 2 | 21:11 | 10 | 25 |
| 3 |
|
FK Renova | 13 | 6 | 4 | 3 | 19:11 | 8 | 22 |
| 4 |
|
FK Bregalnica Štip | 13 | 6 | 4 | 3 | 21:20 | 1 | 22 |
| 5 |
|
KF Shkëndija 79 | 13 | 5 | 6 | 2 | 21:11 | 10 | 21 |
| 6 |
|
FC Struga | 13 | 4 | 7 | 2 | 12:9 | 3 | 19 |
| 7 |
|
FK Rabotnički | 13 | 5 | 3 | 5 | 10:13 | -3 | 18 |
| 8 |
|
Makedonija GP | 13 | 5 | 2 | 6 | 17:25 | -8 | 17 |
| 9 |
|
FK Skopje | 13 | 4 | 4 | 5 | 10:16 | -6 | 16 |
| 10 |
|
GFK Tikvesh | 13 | 2 | 4 | 7 | 10:16 | -6 | 10 |
| 11 |
|
FK Borec | 13 | 2 | 2 | 9 | 10:23 | -13 | 8 |
| 12 |
|
FK Pelister | 13 | 0 | 4 | 9 | 4:18 | -14 | 4 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
