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| 03.04.2021 | 15:00 | Makedonija GP | - | FK AP Brera Strumica | 1:2 (0:2) | |
| 04.04.2021 | 15:00 | FK Pelister | - | Vardar Skopje | 2:0 (1:0) | |
| 15:00 | FK Rabotnički | - | FK Borec | 2:1 (0:0) | ||
| 15:00 | KF Shkupi | - | FK Renova | 1:2 (0:1) | ||
| 15:00 | KF Shkëndija 79 | - | Sileks Kratovo | 2:1 (0:0) | ||
| 15:00 | FC Struga | - | FK Belasica | 3:1 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 25 | 16 | 8 | 1 | 49:16 | 33 | 56 |
| 2 |
|
KF Shkupi | 25 | 13 | 7 | 5 | 36:22 | 14 | 46 |
| 3 |
|
Makedonija GP | 25 | 12 | 5 | 8 | 37:33 | 4 | 41 |
| 4 |
|
FC Struga | 25 | 9 | 10 | 6 | 27:21 | 6 | 37 |
| 5 |
|
FK Rabotnički | 25 | 8 | 12 | 5 | 29:25 | 4 | 36 |
| 6 |
|
FK Borec | 25 | 9 | 6 | 10 | 24:25 | -1 | 33 |
| 7 |
|
FK Pelister | 25 | 8 | 8 | 9 | 24:26 | -2 | 32 |
| 8 |
|
FK AP Brera Strumica | 25 | 9 | 4 | 12 | 20:26 | -6 | 31 |
| 9 |
|
FK Renova | 25 | 6 | 9 | 10 | 28:35 | -7 | 27 |
| 10 |
|
Vardar Skopje | 25 | 6 | 9 | 10 | 29:42 | -13 | 27 |
| 11 |
|
Sileks Kratovo | 25 | 7 | 5 | 13 | 32:32 | 0 | 26 |
| 12 |
|
FK Belasica | 25 | 3 | 5 | 17 | 20:52 | -32 | 14 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
