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| 20.03.2021 | 15:00 | FK AP Brera Strumica | - | FC Struga | 1:0 (1:0) | |
| 15:00 | FK Belasica | - | FK Rabotnički | 1:1 (1:0) | ||
| 15:00 | FK Renova | - | Makedonija GP | 1:2 (1:1) | ||
| 15:00 | Sileks Kratovo | - | KF Shkupi | 1:3 (1:1) | ||
| 15:00 | Vardar Skopje | - | KF Shkëndija 79 | 1:6 (1:2) | ||
| 21.03.2021 | 15:00 | FK Borec | - | FK Pelister | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 24 | 15 | 8 | 1 | 47:15 | 32 | 53 |
| 2 |
|
KF Shkupi | 24 | 13 | 7 | 4 | 35:20 | 15 | 46 |
| 3 |
|
Makedonija GP | 24 | 12 | 5 | 7 | 36:31 | 5 | 41 |
| 4 |
|
FC Struga | 24 | 8 | 10 | 6 | 24:20 | 4 | 34 |
| 5 |
|
FK Rabotnički | 24 | 7 | 12 | 5 | 27:24 | 3 | 33 |
| 6 |
|
FK Borec | 24 | 9 | 6 | 9 | 23:23 | 0 | 33 |
| 7 |
|
FK Pelister | 24 | 7 | 8 | 9 | 22:26 | -4 | 29 |
| 8 |
|
FK AP Brera Strumica | 24 | 8 | 4 | 12 | 18:25 | -7 | 28 |
| 9 |
|
Vardar Skopje | 24 | 6 | 9 | 9 | 29:40 | -11 | 27 |
| 10 |
|
Sileks Kratovo | 24 | 7 | 5 | 12 | 31:30 | 1 | 26 |
| 11 |
|
FK Renova | 24 | 5 | 9 | 10 | 26:34 | -8 | 24 |
| 12 |
|
FK Belasica | 24 | 3 | 5 | 16 | 19:49 | -30 | 14 |
| Champions League Quali. | |
| Relégation | |
| Relégation |
