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| 25.09.2010 | 15:00 | FK Pelister | - | Metalurg Skopje | 0:0 (0:0) | |
| 15:00 | Sileks Kratovo | - | FK Rabotnički | 2:0 (0:0) | ||
| 15:00 | FK Renova | - | FK Bregalnica Štip | 2:0 (1:0) | ||
| 15:00 | Vardar Skopje | - | KF Shkëndija 79 | 0:2 (0:0) | ||
| 15:00 | FK Skopje | - | Napredok Kičevo | 1:0 (0:0) | ||
| 26.09.2010 | 15:00 | FK Turnovo | - | FK Teteks | 1:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Turnovo | 8 | 5 | 1 | 2 | 12:6 | 6 | 16 |
| 2 |
|
Metalurg Skopje | 8 | 4 | 4 | 0 | 10:4 | 6 | 16 |
| 3 |
|
FK Renova | 8 | 4 | 3 | 1 | 9:3 | 6 | 15 |
| 4 |
|
KF Shkëndija 79 | 8 | 4 | 2 | 2 | 13:4 | 9 | 14 |
| 5 |
|
FK Skopje | 8 | 4 | 1 | 3 | 9:7 | 2 | 13 |
| 6 |
|
FK Teteks | 8 | 2 | 5 | 1 | 6:4 | 2 | 11 |
| 7 |
|
FK Rabotnički | 8 | 3 | 2 | 3 | 9:9 | 0 | 11 |
| 8 |
|
Napredok Kičevo | 8 | 3 | 2 | 3 | 5:5 | 0 | 11 |
| 9 |
|
Sileks Kratovo | 8 | 2 | 3 | 3 | 7:12 | -5 | 9 |
| 10 |
|
FK Pelister | 8 | 1 | 2 | 5 | 3:12 | -9 | 5 |
| 11 |
|
FK Bregalnica Štip | 8 | 1 | 1 | 6 | 4:13 | -9 | 4 |
| 12 |
|
Vardar Skopje | 8 | 2 | 0 | 6 | 4:12 | -8 | 3 |
| Champions League Quali. | |
| Europa League | |
| Relégation | |
| Relégation |
