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| 18.09.2010 | 15:30 | FK Skopje | - | FK Pelister | 2:0 (2:0) | |
| 15:30 | Napredok Kičevo | - | Vardar Skopje | 2:1 (0:1) | ||
| 15:30 | FK Teteks | - | FK Renova | 1:1 (1:1) | ||
| 15:30 | FK Bregalnica Štip | - | Sileks Kratovo | 2:2 (1:1) | ||
| 15:30 | FK Rabotnički | - | Metalurg Skopje | 2:2 (0:1) | ||
| 19.09.2010 | 15:30 | KF Shkëndija 79 | - | FK Turnovo | 3:0 (3:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Metalurg Skopje | 7 | 4 | 3 | 0 | 10:4 | 6 | 15 |
| 2 |
|
FK Turnovo | 7 | 4 | 1 | 2 | 11:6 | 5 | 13 |
| 3 |
|
FK Renova | 7 | 3 | 3 | 1 | 7:3 | 4 | 12 |
| 4 |
|
KF Shkëndija 79 | 7 | 3 | 2 | 2 | 11:4 | 7 | 11 |
| 5 |
|
FK Teteks | 7 | 2 | 5 | 0 | 6:3 | 3 | 11 |
| 6 |
|
FK Rabotnički | 7 | 3 | 2 | 2 | 9:7 | 2 | 11 |
| 7 |
|
Napredok Kičevo | 7 | 3 | 2 | 2 | 5:4 | 1 | 11 |
| 8 |
|
FK Skopje | 7 | 3 | 1 | 3 | 8:7 | 1 | 10 |
| 9 |
|
Sileks Kratovo | 7 | 1 | 3 | 3 | 5:12 | -7 | 6 |
| 10 |
|
FK Bregalnica Štip | 7 | 1 | 1 | 5 | 4:11 | -7 | 4 |
| 11 |
|
FK Pelister | 7 | 1 | 1 | 5 | 3:12 | -9 | 4 |
| 12 |
|
Vardar Skopje | 7 | 2 | 0 | 5 | 4:10 | -6 | 3 |
| Champions League Quali. | |
| Europa League | |
| Relégation | |
| Relégation |
