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| H (Match allé) | CF Pachuca | - | CF Monterrey | 3:0 (3:0) | ||
| R (match retour) | CF Monterrey | - | CF Pachuca | -:- | ||
| H (Match allé): 23.04.2025 17:15 | R (match retour): 26.04.2025 17:00 | |||||
| H (Match allé) | Santos Laguna | - | Cruz Azul | 1:1 (0:1) | ||
| R (match retour) | Cruz Azul | - | Santos Laguna | -:- | ||
| H (Match allé): 23.04.2025 19:00 | R (match retour): 26.04.2025 17:00 | |||||
| H (Match allé) | Atlético San Luis | - | Deportivo Toluca | 0:2 (0:1) | ||
| R (match retour) | Deportivo Toluca | - | Atlético San Luis | -:- | ||
| H (Match allé): 24.04.2025 02:00 | R (match retour): 26.04.2025 17:00 | |||||
| H (Match allé) | Club Necaxa | - | FC Juárez | 0:0 | ||
| R (match retour) | FC Juárez | - | Club Necaxa | -:- | ||
| H (Match allé): 24.04.2025 17:00 | R (match retour): 27.04.2025 17:00 | |||||
