 |
 |
|
|
| 22.04.2022 | 16:00 | Puebla FC | - | Club Necaxa | 1:3 (1:2) | |
| 17:00 | FC Juárez | - | Mazatlán FC | 3:0 (0:0) | ||
| 23.04.2022 | 16:00 | UANL Tigres | - | CF América | 3:1 (0:1) | |
| 16:00 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 (0:1) | ||
| 19:00 | CF Pachuca | - | CF Monterrey | 4:0 (0:0) | ||
| 24.04.2022 | 16:00 | Deportivo Toluca | - | Atlas Guadalajara | 2:1 (0:1) | |
| 16:00 | Cruz Azul | - | Atlético San Luis | 2:2 (1:0) | ||
| 18:00 | Santos Laguna | - | Club León | 0:3 (0:2) | ||
| 25.04.2022 | 00:45 | Club Tijuana | - | Gallos Blancos | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 16 | 10 | 3 | 3 | 30:15 | 15 | 33 |
| 2 |
|
Club León | 16 | 10 | 2 | 4 | 31:17 | 14 | 32 |
| 3 |
|
Club Tijuana | 16 | 9 | 4 | 3 | 25:16 | 9 | 31 |
| 4 |
|
Deportivo Toluca | 16 | 8 | 5 | 3 | 24:16 | 8 | 29 |
| 5 |
|
CF América | 16 | 9 | 1 | 6 | 30:19 | 11 | 28 |
| 6 |
|
Deportivo Guadalajara | 16 | 8 | 4 | 4 | 20:17 | 3 | 28 |
| 7 |
|
UANL Tigres | 16 | 8 | 3 | 5 | 26:16 | 10 | 27 |
| 8 |
|
Santos Laguna | 16 | 8 | 3 | 5 | 21:23 | -2 | 27 |
| 9 |
|
Atlético San Luis | 16 | 7 | 3 | 6 | 31:25 | 6 | 24 |
| 10 |
|
Cruz Azul | 16 | 6 | 6 | 4 | 19:14 | 5 | 24 |
| 11 |
|
Club Necaxa | 16 | 7 | 2 | 7 | 25:22 | 3 | 23 |
| 12 |
|
Pumas UNAM | 16 | 5 | 4 | 7 | 22:20 | 2 | 19 |
| 13 |
|
Mazatlán FC | 16 | 5 | 2 | 9 | 16:27 | -11 | 17 |
| 14 |
|
CF Monterrey | 16 | 4 | 4 | 8 | 15:30 | -15 | 16 |
| 15 |
|
Atlas Guadalajara | 16 | 3 | 5 | 8 | 13:21 | -8 | 14 |
| 16 |
|
FC Juárez | 16 | 3 | 4 | 9 | 15:34 | -19 | 13 |
| 17 |
|
Puebla FC | 16 | 2 | 3 | 11 | 17:37 | -20 | 9 |
| 18 |
|
Gallos Blancos | 16 | 1 | 4 | 11 | 9:20 | -11 | 7 |
| Play-off |
