 |
 |
|
|
| 19.04.2022 | 16:00 | Deportivo Toluca | - | FC Juárez | 2:0 (2:0) | |
| 16:00 | Club Necaxa | - | UANL Tigres | 0:2 (0:0) | ||
| 16:00 | Deportivo Guadalajara | - | Club Tijuana | 1:1 (0:0) | ||
| 17:00 | Mazatlán FC | - | Santos Laguna | 1:2 (1:0) | ||
| 19:00 | CF Pachuca | - | Puebla FC | 2:2 (0:0) | ||
| 20.04.2022 | 16:00 | Atlético San Luis | - | Pumas UNAM | 2:1 (1:0) | |
| 16:00 | CF América | - | Club León | 2:1 (1:1) | ||
| 16:00 | CF Monterrey | - | Atlas Guadalajara | 0:0 (0:0) | ||
| 21.04.2022 | 16:00 | Gallos Blancos | - | Cruz Azul | 1:3 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 15 | 9 | 3 | 3 | 26:15 | 11 | 30 |
| 2 |
|
Club León | 15 | 9 | 2 | 4 | 28:17 | 11 | 29 |
| 3 |
|
CF América | 15 | 9 | 1 | 5 | 29:16 | 13 | 28 |
| 4 |
|
Club Tijuana | 15 | 8 | 4 | 3 | 24:16 | 8 | 28 |
| 5 |
|
Santos Laguna | 15 | 8 | 3 | 4 | 21:20 | 1 | 27 |
| 6 |
|
Deportivo Toluca | 15 | 7 | 5 | 3 | 22:15 | 7 | 26 |
| 7 |
|
Deportivo Guadalajara | 15 | 7 | 4 | 4 | 17:16 | 1 | 25 |
| 8 |
|
UANL Tigres | 15 | 7 | 3 | 5 | 23:15 | 8 | 24 |
| 9 |
|
Atlético San Luis | 15 | 7 | 2 | 6 | 29:23 | 6 | 23 |
| 10 |
|
Cruz Azul | 15 | 6 | 5 | 4 | 17:12 | 5 | 23 |
| 11 |
|
Club Necaxa | 15 | 6 | 2 | 7 | 22:21 | 1 | 20 |
| 12 |
|
Pumas UNAM | 15 | 5 | 4 | 6 | 21:17 | 4 | 19 |
| 13 |
|
Mazatlán FC | 15 | 5 | 2 | 8 | 16:24 | -8 | 17 |
| 14 |
|
CF Monterrey | 15 | 4 | 4 | 7 | 15:26 | -11 | 16 |
| 15 |
|
Atlas Guadalajara | 15 | 3 | 5 | 7 | 12:19 | -7 | 14 |
| 16 |
|
FC Juárez | 15 | 2 | 4 | 9 | 12:34 | -22 | 10 |
| 17 |
|
Puebla FC | 15 | 2 | 3 | 10 | 16:34 | -18 | 9 |
| 18 |
|
Gallos Blancos | 15 | 1 | 4 | 10 | 9:19 | -10 | 7 |
| Play-off |
