 |
 |
|
|
| 27.01.2022 | 16:00 | Pumas UNAM | - | CF Monterrey | 4:0 (1:0) | |
| 14.04.2022 | 16:00 | Atlas Guadalajara | - | Mazatlán FC | 3:1 (1:1) | |
| 15.04.2022 | 16:00 | Club Necaxa | - | Atlético San Luis | 3:0 (2:0) | |
| 17:00 | FC Juárez | - | CF Pachuca | 0:2 (0:2) | ||
| 16.04.2022 | 00:45 | Club Tijuana | - | CF América | 4:0 (1:0) | |
| 16:00 | Club León | - | Puebla FC | 4:1 (3:0) | ||
| 16:00 | Cruz Azul | - | Deportivo Guadalajara | 2:1 (0:0) | ||
| 18:00 | Santos Laguna | - | Gallos Blancos | 2:2 (0:1) | ||
| 27.04.2022 | 16:00 | UANL Tigres | - | Deportivo Toluca | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club León | 14 | 9 | 2 | 3 | 27:15 | 12 | 29 |
| 2 |
|
CF Pachuca | 14 | 9 | 2 | 3 | 24:13 | 11 | 29 |
| 3 |
|
Club Tijuana | 14 | 8 | 3 | 3 | 23:15 | 8 | 27 |
| 4 |
|
CF América | 14 | 8 | 1 | 5 | 27:15 | 12 | 25 |
| 5 |
|
Deportivo Guadalajara | 14 | 7 | 3 | 4 | 16:15 | 1 | 24 |
| 6 |
|
Santos Laguna | 14 | 7 | 3 | 4 | 19:19 | 0 | 24 |
| 7 |
|
Deportivo Toluca | 14 | 6 | 5 | 3 | 20:15 | 5 | 23 |
| 8 |
|
UANL Tigres | 14 | 6 | 3 | 5 | 21:15 | 6 | 21 |
| 9 |
|
Atlético San Luis | 14 | 6 | 2 | 6 | 27:22 | 5 | 20 |
| 10 |
|
Club Necaxa | 14 | 6 | 2 | 6 | 22:19 | 3 | 20 |
| 11 |
|
Cruz Azul | 14 | 5 | 5 | 4 | 14:11 | 3 | 20 |
| 12 |
|
Pumas UNAM | 14 | 5 | 4 | 5 | 20:15 | 5 | 19 |
| 13 |
|
Mazatlán FC | 14 | 5 | 2 | 7 | 15:22 | -7 | 17 |
| 14 |
|
CF Monterrey | 14 | 4 | 3 | 7 | 15:26 | -11 | 15 |
| 15 |
|
Atlas Guadalajara | 14 | 3 | 4 | 7 | 12:19 | -7 | 13 |
| 16 |
|
FC Juárez | 14 | 2 | 4 | 8 | 12:32 | -20 | 10 |
| 17 |
|
Puebla FC | 14 | 2 | 2 | 10 | 14:32 | -18 | 8 |
| 18 |
|
Gallos Blancos | 14 | 1 | 4 | 9 | 8:16 | -8 | 7 |
| Play-off |
