 |
 |
|
|
| 27.08.2021 | 16:00 | Puebla FC | - | Gallos Blancos | 0:1 (0:1) | |
| 17:00 | Mazatlán FC | - | Atlético San Luis | 3:1 (3:1) | ||
| 28.08.2021 | 00:45 | Club Tijuana | - | CF Monterrey | 1:0 (1:0) | |
| 16:00 | Club León | - | CF América | 2:2 (0:2) | ||
| 16:00 | UANL Tigres | - | Atlas Guadalajara | 0:1 (0:0) | ||
| 16:00 | Deportivo Guadalajara | - | Club Necaxa | 2:0 (1:0) | ||
| 29.08.2021 | 16:00 | Cruz Azul | - | CF Pachuca | 0:0 (0:0) | |
| 16:00 | Deportivo Toluca | - | Pumas UNAM | 2:2 (1:1) | ||
| 18:00 | Santos Laguna | - | FC Juárez | 3:1 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 7 | 4 | 2 | 1 | 11:5 | 6 | 14 |
| 2 |
|
Deportivo Toluca | 7 | 4 | 2 | 1 | 12:7 | 5 | 14 |
| 3 |
|
Club León | 7 | 4 | 2 | 1 | 9:6 | 3 | 14 |
| 4 |
|
CF América | 7 | 3 | 4 | 0 | 13:8 | 5 | 13 |
| 5 |
|
Club Necaxa | 7 | 4 | 1 | 2 | 12:8 | 4 | 13 |
| 6 |
|
Gallos Blancos | 7 | 4 | 0 | 3 | 9:7 | 2 | 12 |
| 7 |
|
CF Monterrey | 7 | 3 | 2 | 2 | 14:8 | 6 | 11 |
| 8 |
|
Santos Laguna | 7 | 3 | 2 | 2 | 10:9 | 1 | 11 |
| 9 |
|
Puebla FC | 7 | 3 | 1 | 3 | 12:14 | -2 | 10 |
| 10 |
|
Mazatlán FC | 7 | 2 | 2 | 3 | 10:13 | -3 | 8 |
| 11 |
|
Pumas UNAM | 7 | 2 | 2 | 3 | 12:16 | -4 | 8 |
| 12 |
|
Deportivo Guadalajara | 7 | 2 | 2 | 3 | 8:12 | -4 | 8 |
| 13 |
|
Atlético San Luis | 7 | 2 | 1 | 4 | 13:14 | -1 | 7 |
| 14 |
|
Cruz Azul | 7 | 1 | 4 | 2 | 5:6 | -1 | 7 |
| 15 |
|
CF Pachuca | 7 | 1 | 4 | 2 | 6:8 | -2 | 7 |
| 16 |
|
Atlas Guadalajara | 7 | 2 | 1 | 4 | 6:10 | -4 | 7 |
| 17 |
|
UANL Tigres | 7 | 1 | 2 | 4 | 8:10 | -2 | 5 |
| 18 |
|
FC Juárez | 7 | 0 | 2 | 5 | 5:14 | -9 | 2 |
| Play-off |
