 |
 |
|
|
| 17.08.2021 | 16:00 | UANL Tigres | - | Gallos Blancos | 3:0 (1:0) | |
| 16:00 | Deportivo Toluca | - | Mazatlán FC | 3:1 (0:0) | ||
| 16:00 | Club Necaxa | - | Pumas UNAM | 1:1 (1:0) | ||
| 18.08.2021 | 00:45 | Club Tijuana | - | Puebla FC | 3:0 (1:0) | |
| 16:00 | Cruz Azul | - | CF Monterrey | 2:1 (2:0) | ||
| 16:00 | Deportivo Guadalajara | - | Club León | 1:2 (1:1) | ||
| 17:00 | FC Juárez | - | CF América | 1:1 (0:0) | ||
| 18:00 | Santos Laguna | - | Atlas Guadalajara | 3:1 (0:1) | ||
| 03.11.2021 | 16:30 | CF Pachuca | - | Atlético San Luis | 1:3 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club León | 5 | 4 | 0 | 1 | 6:3 | 3 | 12 |
| 2 |
|
CF América | 5 | 3 | 2 | 0 | 10:5 | 5 | 11 |
| 3 |
|
CF Monterrey | 5 | 3 | 1 | 1 | 13:6 | 7 | 10 |
| 4 |
|
Club Tijuana | 5 | 3 | 1 | 1 | 9:4 | 5 | 10 |
| 5 |
|
Deportivo Toluca | 5 | 3 | 1 | 1 | 8:4 | 4 | 10 |
| 6 |
|
Club Necaxa | 5 | 3 | 1 | 1 | 8:5 | 3 | 10 |
| 7 |
|
Gallos Blancos | 5 | 3 | 0 | 2 | 7:5 | 2 | 9 |
| 8 |
|
Santos Laguna | 5 | 2 | 1 | 2 | 6:7 | -1 | 7 |
| 9 |
|
Pumas UNAM | 5 | 2 | 1 | 2 | 9:11 | -2 | 7 |
| 10 |
|
Puebla FC | 5 | 2 | 1 | 2 | 9:12 | -3 | 7 |
| 11 |
|
Atlético San Luis | 5 | 2 | 0 | 3 | 12:11 | 1 | 6 |
| 12 |
|
UANL Tigres | 5 | 1 | 2 | 2 | 6:6 | 0 | 5 |
| 13 |
|
Cruz Azul | 5 | 1 | 2 | 2 | 5:6 | -1 | 5 |
| 14 |
|
Atlas Guadalajara | 5 | 1 | 1 | 3 | 4:8 | -4 | 4 |
| 15 |
|
Deportivo Guadalajara | 5 | 1 | 1 | 3 | 5:11 | -6 | 4 |
| 16 |
|
CF Pachuca | 5 | 0 | 3 | 2 | 4:7 | -3 | 3 |
| 17 |
|
FC Juárez | 5 | 0 | 2 | 3 | 3:7 | -4 | 2 |
| 18 |
|
Mazatlán FC | 5 | 0 | 2 | 3 | 4:10 | -6 | 2 |
| Play-off |
