 |
 |
| H (Match allé) | CF América | - | Pumas UNAM | 1:0 (1:0) | ||
| R (match retour) | Pumas UNAM | - | CF América | 0:1 (0:1) | ||
| H (Match allé): 23.04.2025 18:00 | R (match retour): 26.04.2025 18:00 | vainqueur: CF América | ||||
| H (Match allé) | Santos Laguna | - | UANL Tigres | 2:2 (1:1) | ||
| R (match retour) | UANL Tigres | - | Santos Laguna | -:- | ||
| H (Match allé): 24.04.2025 17:00 | R (match retour): 27.04.2025 17:00 | |||||
| H (Match allé) | Atlas Guadalajara | - | Deportivo Toluca | 2:2 (1:1) | ||
| R (match retour) | Deportivo Toluca | - | Atlas Guadalajara | -:- | ||
| H (Match allé): 24.04.2025 17:00 | R (match retour): 27.04.2025 17:00 | |||||
| H (Match allé) | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| R (match retour) | CF Pachuca | - | Deportivo Guadalajara | -:- | ||
| H (Match allé): 24.04.2025 18:00 | R (match retour): 27.04.2025 18:00 | |||||
