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| H (Match allé) | UANL Tigres | - | Santos Laguna | -:- | ||
| R (match retour) | Santos Laguna | - | UANL Tigres | -:- | ||
| H (Match allé): 23.04.2025 | R (match retour): 26.04.2025 | |||||
| H (Match allé) | Deportivo Toluca | - | Atlas Guadalajara | -:- | ||
| R (match retour) | Atlas Guadalajara | - | Deportivo Toluca | -:- | ||
| H (Match allé): 23.04.2025 | R (match retour): 26.04.2025 | |||||
| H (Match allé) | Pumas UNAM | - | CF América | -:- | ||
| R (match retour) | CF América | - | Pumas UNAM | -:- | ||
| H (Match allé): 23.04.2025 | R (match retour): 26.04.2025 | |||||
| H (Match allé) | CF Pachuca | - | Deportivo Guadalajara | -:- | ||
| R (match retour) | Deportivo Guadalajara | - | CF Pachuca | -:- | ||
| H (Match allé): 23.04.2025 | R (match retour): 26.04.2025 | |||||
