 |
 |
|
| 22.10.2021 | 18:45 | Mazatlán FC | - | Gallos Blancos | 2:0 (0:0) | |
| 23.10.2021 | 18:15 | Deportivo Guadalajara | - | Cruz Azul | 2:1 (1:0) | |
| 18:30 | CF Monterrey | - | Club Necaxa | 1:3 (0:2) | ||
| 18:45 | Puebla FC | - | Club León | 2:1 (1:0) | ||
| 19:00 | CF América | - | UANL Tigres | 3:3 (0:0) | ||
| 24.10.2021 | 16:00 | Santos Laguna | - | Deportivo Toluca | 3:1 (1:1) | |
| 18:30 | Pumas UNAM | - | Club Tijuana | 2:2 (1:0) | ||
| 18:45 | Atlético San Luis | - | Atlas Guadalajara | 0:1 (0:1) | ||
| 25.10.2021 | 16:00 | CF Pachuca | - | FC Juárez | 3:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 15 | 11 | 3 | 1 | 41:24 | 17 | 36 |
| 2 |
|
CF América | 15 | 9 | 3 | 3 | 29:18 | 11 | 30 |
| 3 |
|
Club León | 15 | 9 | 3 | 3 | 26:22 | 4 | 30 |
| 4 |
|
UANL Tigres | 15 | 8 | 5 | 2 | 28:13 | 15 | 29 |
| 5 |
|
Mazatlán FC | 15 | 8 | 4 | 3 | 24:18 | 6 | 28 |
| 6 |
|
CF Pachuca | 15 | 8 | 3 | 4 | 34:16 | 18 | 27 |
| 7 |
|
Atlas Guadalajara | 15 | 7 | 4 | 4 | 26:20 | 6 | 25 |
| 8 |
|
Santos Laguna | 15 | 7 | 3 | 5 | 22:17 | 5 | 24 |
| 9 |
|
Deportivo Guadalajara | 15 | 5 | 6 | 4 | 28:24 | 4 | 21 |
| 10 |
|
Gallos Blancos | 15 | 5 | 5 | 5 | 12:12 | 0 | 20 |
| 11 |
|
Club Tijuana | 15 | 5 | 2 | 8 | 22:27 | -5 | 17 |
| 12 |
|
Deportivo Toluca | 15 | 4 | 4 | 7 | 19:22 | -3 | 16 |
| 13 |
|
Atlético San Luis | 15 | 4 | 4 | 7 | 22:34 | -12 | 16 |
| 14 |
|
FC Juárez | 15 | 4 | 3 | 8 | 22:25 | -3 | 15 |
| 15 |
|
Cruz Azul | 15 | 3 | 4 | 8 | 17:32 | -15 | 13 |
| 16 |
|
Pumas UNAM | 15 | 2 | 5 | 8 | 15:28 | -13 | 11 |
| 17 |
|
Puebla FC | 15 | 2 | 3 | 10 | 20:37 | -17 | 9 |
| 18 |
|
CF Monterrey | 15 | 0 | 4 | 11 | 9:27 | -18 | 4 |
| Play-off |
