 |
 |
|
|
| 09.04.2021 | 18:15 | Club Necaxa | - | Pumas UNAM | 3:0 (1:0) | |
| 19:30 | FC Juárez | - | Atlético San Luis | 2:0 (2:0) | ||
| 10.04.2021 | 16:00 | UANL Tigres | - | CF América | 3:3 (0:1) | |
| 18:00 | Cruz Azul | - | Deportivo Guadalajara | 3:2 (2:0) | ||
| 18:30 | Atlas Guadalajara | - | Club León | 0:0 (0:0) | ||
| 11.04.2021 | 18:30 | Deportivo Toluca | - | CF Monterrey | 1:0 (0:0) | |
| 18:30 | Gallos Blancos | - | Santos Laguna | 0:0 (0:0) | ||
| 21:45 | Club Tijuana | - | Mazatlán FC | 1:0 (1:0) | ||
| 12.04.2021 | 16:30 | CF Pachuca | - | Puebla FC | 5:1 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 14 | 9 | 3 | 2 | 40:20 | 20 | 43 |
| 2 |
|
Atlas Guadalajara | 14 | 8 | 2 | 4 | 24:18 | 6 | 38 |
| 3 |
|
Club León | 14 | 8 | 4 | 2 | 25:16 | 9 | 35 |
| 4 |
|
Santos Laguna | 14 | 7 | 3 | 4 | 26:21 | 5 | 33 |
| 5 |
|
Deportivo Guadalajara | 14 | 7 | 4 | 3 | 26:16 | 10 | 32 |
| 6 |
|
UANL Tigres | 14 | 7 | 4 | 3 | 24:16 | 8 | 32 |
| 7 |
|
Club Tijuana | 14 | 7 | 1 | 6 | 23:21 | 2 | 31 |
| 8 |
|
Deportivo Toluca | 14 | 5 | 5 | 4 | 21:19 | 2 | 28 |
| 9 |
|
Pumas UNAM | 14 | 6 | 2 | 6 | 20:18 | 2 | 28 |
| 10 |
|
CF Monterrey | 14 | 6 | 2 | 6 | 21:19 | 2 | 27 |
| 11 |
|
Club Necaxa | 14 | 5 | 2 | 7 | 21:21 | 0 | 27 |
| 12 |
|
Cruz Azul | 14 | 6 | 1 | 7 | 22:24 | -2 | 27 |
| 13 |
|
FC Juárez | 14 | 6 | 1 | 7 | 19:17 | 2 | 26 |
| 14 |
|
Mazatlán FC | 14 | 4 | 4 | 6 | 16:25 | -9 | 26 |
| 15 |
|
Puebla FC | 14 | 5 | 3 | 6 | 22:24 | -2 | 25 |
| 16 |
|
Gallos Blancos | 14 | 3 | 2 | 9 | 17:28 | -11 | 17 |
| 17 |
|
Atlético San Luis | 14 | 1 | 2 | 11 | 11:39 | -28 | 17 |
| 18 |
|
CF América | 14 | 3 | 1 | 10 | 18:34 | -16 | 16 |
| Play-off |
