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| 10.09.2022 | 16:00 | UANL Tigres | - | Santos Laguna | 2:1 (0:0) | |
| 16:00 | Cruz Azul | - | FC Juárez | 3:3 (2:1) | ||
| 16:00 | Gallos Blancos | - | CF Pachuca | 1:0 (0:0) | ||
| 16:00 | Club León | - | Mazatlán FC | 3:4 (0:1) | ||
| 16:00 | Deportivo Toluca | - | Pumas UNAM | 2:1 (2:0) | ||
| 18:00 | Puebla FC | - | CF América | 1:3 (1:2) | ||
| 19:00 | Club Tijuana | - | CF Monterrey | 0:4 (0:1) | ||
| 11.09.2022 | 16:00 | Deportivo Guadalajara | - | Atlético San Luis | 2:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 10 | 6 | 3 | 1 | 28:11 | 17 | 21 |
| 2 |
|
CF América | 10 | 5 | 3 | 2 | 21:14 | 7 | 18 |
| 3 |
|
Cruz Azul | 11 | 4 | 4 | 3 | 24:18 | 6 | 16 |
| 4 |
|
Pumas UNAM | 11 | 4 | 3 | 4 | 13:15 | -2 | 15 |
| 5 |
|
Deportivo Toluca | 10 | 4 | 2 | 4 | 26:23 | 3 | 14 |
| 6 |
|
FC Juárez | 11 | 3 | 5 | 3 | 17:17 | 0 | 14 |
| 7 |
|
CF Pachuca | 11 | 4 | 1 | 6 | 13:19 | -6 | 13 |
| 8 |
|
Gallos Blancos | 11 | 4 | 1 | 6 | 12:22 | -10 | 13 |
| 9 |
|
Puebla FC | 11 | 2 | 2 | 7 | 15:30 | -15 | 8 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 11 | 8 | 2 | 1 | 22:11 | 11 | 26 |
| 2 |
|
Santos Laguna | 11 | 7 | 1 | 3 | 19:11 | 8 | 22 |
| 3 |
|
Mazatlán FC | 11 | 7 | 1 | 3 | 17:14 | 3 | 22 |
| 4 |
|
CF Monterrey | 10 | 7 | 0 | 3 | 24:10 | 14 | 21 |
| 5 |
|
Atlas Guadalajara | 10 | 4 | 2 | 4 | 13:13 | 0 | 14 |
| 6 |
|
Atlético San Luis | 11 | 3 | 2 | 6 | 17:22 | -5 | 11 |
| 7 |
|
Club Tijuana | 11 | 3 | 2 | 6 | 10:17 | -7 | 11 |
| 8 |
|
UANL Tigres | 10 | 3 | 0 | 7 | 9:15 | -6 | 9 |
| 9 |
|
Club León | 11 | 0 | 2 | 9 | 13:31 | -18 | 2 |
| Play-off | |
| Play-off |
