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| 12.02.2022 | 16:00 | UANL Tigres | - | CF Monterrey | 1:0 (1:0) | |
| 16:00 | Gallos Blancos | - | Pumas UNAM | 0:1 (0:0) | ||
| 16:00 | Club León | - | Atlético San Luis | 2:1 (1:0) | ||
| 17:00 | FC Juárez | - | CF América | 1:0 (0:0) | ||
| 19:00 | Club Necaxa | - | CF Pachuca | 2:2 (0:0) | ||
| 19:30 | Mazatlán FC | - | Club Tijuana | 1:2 (0:1) | ||
| 22:45 | Santos Laguna | - | Atlas Guadalajara | 5:3 (2:1) | ||
| 23:00 | Puebla FC | - | Deportivo Toluca | 1:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 5 | 4 | 0 | 1 | 13:5 | 8 | 12 |
| 2 |
|
CF América | 5 | 4 | 0 | 1 | 8:1 | 7 | 12 |
| 3 |
|
Deportivo Toluca | 6 | 3 | 1 | 2 | 14:11 | 3 | 10 |
| 4 |
|
Pumas UNAM | 6 | 3 | 0 | 3 | 9:5 | 4 | 9 |
| 5 |
|
FC Juárez | 5 | 2 | 1 | 2 | 6:7 | -1 | 7 |
| 6 |
|
Club Necaxa | 5 | 1 | 3 | 1 | 6:11 | -5 | 6 |
| 7 |
|
Puebla FC | 5 | 1 | 2 | 2 | 5:5 | 0 | 5 |
| 8 |
|
Gallos Blancos | 6 | 1 | 1 | 4 | 4:11 | -7 | 4 |
| 9 |
|
CF Pachuca | 5 | 0 | 2 | 3 | 6:15 | -9 | 2 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 5 | 3 | 2 | 0 | 7:4 | 3 | 11 |
| 2 |
|
Atlas Guadalajara | 5 | 3 | 1 | 1 | 10:7 | 3 | 10 |
| 3 |
|
UANL Tigres | 5 | 3 | 1 | 1 | 7:4 | 3 | 10 |
| 4 |
|
Santos Laguna | 5 | 2 | 1 | 2 | 8:6 | 2 | 7 |
| 5 |
|
Club León | 5 | 2 | 1 | 2 | 6:6 | 0 | 7 |
| 6 |
|
Club Tijuana | 6 | 2 | 1 | 3 | 6:10 | -4 | 7 |
| 7 |
|
Mazatlán FC | 5 | 1 | 2 | 2 | 7:8 | -1 | 5 |
| 8 |
|
CF Monterrey | 6 | 0 | 4 | 2 | 6:8 | -2 | 4 |
| 9 |
|
Atlético San Luis | 6 | 1 | 1 | 4 | 5:9 | -4 | 4 |
| Play-off | |
| Play-off |
