 |
 |
|
| 11.09.2021 | 16:00 | Gallos Blancos | - | Club Tijuana | 1:2 (1:1) | |
| 16:00 | Deportivo Toluca | - | CF América | 1:0 (0:0) | ||
| 16:00 | Club León | - | Atlas Guadalajara | 2:1 (0:0) | ||
| 16:00 | Santos Laguna | - | Mazatlán FC | 4:2 (2:1) | ||
| 17:00 | FC Juárez | - | CF Pachuca | 1:0 (1:0) | ||
| 17:00 | Deportivo Guadalajara | - | UANL Tigres | 3:1 (2:1) | ||
| 23:00 | Atlético San Luis | - | CF Monterrey | 2:1 (1:0) | ||
| 20.10.2021 | 23:00 | Puebla FC | - | Cruz Azul | 1:2 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 7 | 5 | 2 | 0 | 19:8 | 11 | 17 |
| 2 |
|
Deportivo Guadalajara | 7 | 5 | 1 | 1 | 24:7 | 17 | 16 |
| 3 |
|
Deportivo Toluca | 7 | 5 | 1 | 1 | 13:9 | 4 | 16 |
| 4 |
|
Pumas UNAM | 7 | 4 | 2 | 1 | 13:8 | 5 | 14 |
| 5 |
|
Club Necaxa | 7 | 4 | 1 | 2 | 11:6 | 5 | 13 |
| 6 |
|
Cruz Azul | 7 | 4 | 1 | 2 | 9:7 | 2 | 13 |
| 7 |
|
CF Pachuca | 7 | 4 | 1 | 2 | 8:6 | 2 | 13 |
| 8 |
|
CF Monterrey | 8 | 3 | 2 | 3 | 11:12 | -1 | 11 |
| 9 |
|
Club Tijuana | 7 | 3 | 1 | 3 | 8:10 | -2 | 10 |
| 10 |
|
Atlas Guadalajara | 7 | 3 | 0 | 4 | 20:15 | 5 | 9 |
| 11 |
|
Mazatlán FC | 7 | 3 | 0 | 4 | 14:22 | -8 | 9 |
| 12 |
|
Gallos Blancos | 8 | 2 | 2 | 4 | 10:11 | -1 | 8 |
| 13 |
|
UANL Tigres | 7 | 2 | 1 | 4 | 10:14 | -4 | 7 |
| 14 |
|
Club León | 7 | 2 | 1 | 4 | 8:15 | -7 | 7 |
| 15 |
|
CF América | 7 | 2 | 0 | 5 | 8:9 | -1 | 6 |
| 16 |
|
Puebla FC | 7 | 2 | 0 | 5 | 10:14 | -4 | 6 |
| 17 |
|
FC Juárez | 7 | 1 | 2 | 4 | 6:11 | -5 | 5 |
| 18 |
|
Atlético San Luis | 7 | 1 | 0 | 6 | 7:25 | -18 | 3 |
| Play-off |
