 |
 |
|
| 21.08.2021 | 16:00 | UANL Tigres | - | Mazatlán FC | 2:3 (2:0) | |
| 16:00 | Cruz Azul | - | Deportivo Toluca | 1:2 (0:2) | ||
| 16:00 | Santos Laguna | - | Atlético San Luis | 2:0 (0:0) | ||
| 16:45 | Club León | - | CF Monterrey | 0:1 (0:0) | ||
| 17:00 | FC Juárez | - | Gallos Blancos | 1:1 (0:0) | ||
| 17:00 | Deportivo Guadalajara | - | Club Necaxa | 1:2 (0:2) | ||
| 23:00 | Puebla FC | - | Club Tijuana | 3:0 (1:0) | ||
| 15.09.2021 | 18:00 | CF Pachuca | - | Pumas UNAM | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 5 | 3 | 1 | 1 | 14:5 | 9 | 10 |
| 2 |
|
Club Necaxa | 5 | 3 | 1 | 1 | 8:3 | 5 | 10 |
| 3 |
|
Deportivo Toluca | 5 | 3 | 1 | 1 | 9:9 | 0 | 10 |
| 4 |
|
Atlas Guadalajara | 4 | 3 | 0 | 1 | 17:6 | 11 | 9 |
| 5 |
|
CF Pachuca | 4 | 3 | 0 | 1 | 6:4 | 2 | 9 |
| 6 |
|
Mazatlán FC | 4 | 3 | 0 | 1 | 9:8 | 1 | 9 |
| 7 |
|
Santos Laguna | 4 | 2 | 2 | 0 | 9:5 | 4 | 8 |
| 8 |
|
Pumas UNAM | 5 | 2 | 2 | 1 | 8:7 | 1 | 8 |
| 9 |
|
Gallos Blancos | 5 | 2 | 1 | 2 | 7:6 | 1 | 7 |
| 10 |
|
Cruz Azul | 5 | 2 | 1 | 2 | 6:6 | 0 | 7 |
| 11 |
|
CF Monterrey | 5 | 2 | 1 | 2 | 8:9 | -1 | 7 |
| 12 |
|
Puebla FC | 4 | 2 | 0 | 2 | 9:6 | 3 | 6 |
| 13 |
|
Club Tijuana | 4 | 1 | 1 | 2 | 4:7 | -3 | 4 |
| 14 |
|
CF América | 4 | 1 | 0 | 3 | 4:6 | -2 | 3 |
| 15 |
|
UANL Tigres | 4 | 1 | 0 | 3 | 6:9 | -3 | 3 |
| 16 |
|
FC Juárez | 4 | 0 | 2 | 2 | 5:7 | -2 | 2 |
| 17 |
|
Club León | 4 | 0 | 1 | 3 | 3:12 | -9 | 1 |
| 18 |
|
Atlético San Luis | 5 | 0 | 0 | 5 | 4:21 | -17 | 0 |
| Play-off |
