 |
 |
|
| 06.11.2021 | 16:00 | UANL Tigres | - | Santos Laguna | 4:0 (1:0) | |
| 16:00 | Cruz Azul | - | Puebla FC | 0:2 (0:1) | ||
| 16:00 | Deportivo Toluca | - | Pumas UNAM | 3:1 (2:0) | ||
| 17:00 | FC Juárez | - | Club Tijuana | 1:3 (0:1) | ||
| 18:00 | CF Pachuca | - | CF América | 3:1 (1:1) | ||
| 19:00 | Club Necaxa | - | Club León | 0:1 (0:0) | ||
| 23:00 | Atlético San Luis | - | Mazatlán FC | 1:2 (0:0) | ||
| 23:00 | Deportivo Guadalajara | - | Atlas Guadalajara | 3:0 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 14 | 10 | 3 | 1 | 46:15 | 31 | 33 |
| 2 |
|
Deportivo Toluca | 15 | 9 | 5 | 1 | 26:14 | 12 | 32 |
| 3 |
|
Pumas UNAM | 14 | 9 | 2 | 3 | 24:13 | 11 | 29 |
| 4 |
|
Santos Laguna | 14 | 8 | 4 | 2 | 29:18 | 11 | 28 |
| 5 |
|
CF Pachuca | 14 | 8 | 3 | 3 | 19:12 | 7 | 27 |
| 6 |
|
UANL Tigres | 14 | 7 | 3 | 4 | 25:16 | 9 | 24 |
| 7 |
|
Cruz Azul | 15 | 7 | 3 | 5 | 18:17 | 1 | 24 |
| 8 |
|
Club Tijuana | 14 | 7 | 1 | 6 | 20:21 | -1 | 22 |
| 9 |
|
Club León | 14 | 6 | 3 | 5 | 21:20 | 1 | 21 |
| 10 |
|
Club Necaxa | 14 | 6 | 2 | 6 | 21:16 | 5 | 20 |
| 11 |
|
Atlas Guadalajara | 14 | 6 | 1 | 7 | 31:29 | 2 | 19 |
| 12 |
|
CF Monterrey | 14 | 5 | 4 | 5 | 21:24 | -3 | 19 |
| 13 |
|
Puebla FC | 14 | 5 | 3 | 6 | 23:24 | -1 | 18 |
| 14 |
|
CF América | 14 | 4 | 1 | 9 | 19:24 | -5 | 13 |
| 15 |
|
Mazatlán FC | 15 | 4 | 1 | 10 | 23:46 | -23 | 13 |
| 16 |
|
Gallos Blancos | 14 | 2 | 4 | 8 | 16:21 | -5 | 10 |
| 17 |
|
FC Juárez | 14 | 1 | 2 | 11 | 10:29 | -19 | 5 |
| 18 |
|
Atlético San Luis | 15 | 1 | 1 | 13 | 11:44 | -33 | 4 |
| Play-off |
