 |
 |
|
| 16.10.2021 | 16:00 | Deportivo Toluca | - | Cruz Azul | 1:1 (0:1) | |
| 16:00 | Atlas Guadalajara | - | Club Necaxa | 1:4 (1:0) | ||
| 16:00 | Club León | - | Mazatlán FC | 4:1 (2:0) | ||
| 16:00 | Santos Laguna | - | CF Monterrey | 1:1 (0:0) | ||
| 18:00 | CF Pachuca | - | FC Juárez | 4:1 (2:0) | ||
| 23:00 | CF América | - | Club Tijuana | 4:2 (1:1) | ||
| 23:00 | Puebla FC | - | Gallos Blancos | 2:2 (1:0) | ||
| 23:00 | Atlético San Luis | - | UANL Tigres | 0:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 12 | 7 | 4 | 1 | 27:13 | 14 | 25 |
| 2 |
|
Deportivo Guadalajara | 11 | 7 | 3 | 1 | 31:11 | 20 | 24 |
| 3 |
|
Pumas UNAM | 11 | 7 | 2 | 2 | 20:10 | 10 | 23 |
| 4 |
|
Deportivo Toluca | 12 | 6 | 5 | 1 | 19:13 | 6 | 23 |
| 5 |
|
Cruz Azul | 12 | 7 | 2 | 3 | 16:11 | 5 | 23 |
| 6 |
|
CF Pachuca | 12 | 6 | 3 | 3 | 15:11 | 4 | 21 |
| 7 |
|
UANL Tigres | 12 | 6 | 2 | 4 | 21:16 | 5 | 20 |
| 8 |
|
CF Monterrey | 12 | 5 | 3 | 4 | 20:17 | 3 | 18 |
| 9 |
|
Club Necaxa | 11 | 5 | 2 | 4 | 16:13 | 3 | 17 |
| 10 |
|
Club Tijuana | 11 | 5 | 1 | 5 | 14:17 | -3 | 16 |
| 11 |
|
Atlas Guadalajara | 11 | 5 | 0 | 6 | 28:25 | 3 | 15 |
| 12 |
|
Club León | 11 | 4 | 2 | 5 | 18:19 | -1 | 14 |
| 13 |
|
CF América | 11 | 4 | 0 | 7 | 16:16 | 0 | 12 |
| 14 |
|
Puebla FC | 12 | 3 | 3 | 6 | 19:23 | -4 | 12 |
| 15 |
|
Gallos Blancos | 12 | 2 | 4 | 6 | 14:17 | -3 | 10 |
| 16 |
|
Mazatlán FC | 12 | 3 | 1 | 8 | 17:37 | -20 | 10 |
| 17 |
|
FC Juárez | 11 | 1 | 2 | 8 | 8:23 | -15 | 5 |
| 18 |
|
Atlético San Luis | 12 | 1 | 1 | 10 | 9:36 | -27 | 4 |
| Play-off |
