 |
 |
|
| 09.10.2021 | 16:00 | UANL Tigres | - | Club Necaxa | 4:0 (1:0) | |
| 16:00 | CF Monterrey | - | Atlético San Luis | 3:1 (2:0) | ||
| 16:30 | Mazatlán FC | - | Santos Laguna | 1:2 (1:1) | ||
| 17:00 | Pumas UNAM | - | CF Pachuca | 2:0 (0:0) | ||
| 17:00 | FC Juárez | - | Cruz Azul | 0:2 (0:1) | ||
| 17:00 | Deportivo Guadalajara | - | Club León | 1:1 (1:1) | ||
| 18:30 | Gallos Blancos | - | Deportivo Toluca | 1:1 (1:1) | ||
| 19:00 | Club Tijuana | - | Puebla FC | 3:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 11 | 7 | 3 | 1 | 31:11 | 20 | 24 |
| 2 |
|
Santos Laguna | 11 | 7 | 3 | 1 | 26:12 | 14 | 24 |
| 3 |
|
Pumas UNAM | 11 | 7 | 2 | 2 | 20:10 | 10 | 23 |
| 4 |
|
Deportivo Toluca | 11 | 6 | 4 | 1 | 18:12 | 6 | 22 |
| 5 |
|
Cruz Azul | 11 | 7 | 1 | 3 | 15:10 | 5 | 22 |
| 6 |
|
CF Pachuca | 11 | 5 | 3 | 3 | 11:10 | 1 | 18 |
| 7 |
|
CF Monterrey | 11 | 5 | 2 | 4 | 19:16 | 3 | 17 |
|
UANL Tigres | 11 | 5 | 2 | 4 | 19:16 | 3 | 17 | |
| 9 |
|
Club Tijuana | 10 | 5 | 1 | 4 | 12:13 | -1 | 16 |
| 10 |
|
Atlas Guadalajara | 10 | 5 | 0 | 5 | 27:21 | 6 | 15 |
| 11 |
|
Club Necaxa | 10 | 4 | 2 | 4 | 12:12 | 0 | 14 |
| 12 |
|
Puebla FC | 11 | 3 | 2 | 6 | 17:21 | -4 | 11 |
| 13 |
|
Club León | 10 | 3 | 2 | 5 | 14:18 | -4 | 11 |
| 14 |
|
Mazatlán FC | 11 | 3 | 1 | 7 | 16:33 | -17 | 10 |
| 15 |
|
CF América | 10 | 3 | 0 | 7 | 12:14 | -2 | 9 |
| 16 |
|
Gallos Blancos | 11 | 2 | 3 | 6 | 12:15 | -3 | 9 |
| 17 |
|
FC Juárez | 10 | 1 | 2 | 7 | 7:19 | -12 | 5 |
| 18 |
|
Atlético San Luis | 11 | 1 | 1 | 9 | 9:34 | -25 | 4 |
| Play-off |
