 |
 |
|
| 25.09.2021 | 15:30 | CF Monterrey | - | Mazatlán FC | 4:0 (1:0) | |
| 16:00 | Cruz Azul | - | CF Pachuca | 1:2 (1:0) | ||
| 16:00 | Gallos Blancos | - | CF América | 1:2 (0:1) | ||
| 16:00 | Club León | - | UANL Tigres | 1:2 (1:1) | ||
| 16:00 | Santos Laguna | - | Atlas Guadalajara | 1:2 (0:2) | ||
| 17:00 | Pumas UNAM | - | FC Juárez | 3:0 (2:0) | ||
| 17:00 | Deportivo Guadalajara | - | Atlético San Luis | 1:1 (1:1) | ||
| 23:00 | Puebla FC | - | Deportivo Toluca | 2:2 (2:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 9 | 6 | 2 | 1 | 29:10 | 19 | 20 |
| 2 |
|
Santos Laguna | 9 | 5 | 3 | 1 | 21:11 | 10 | 18 |
| 3 |
|
Deportivo Toluca | 9 | 5 | 3 | 1 | 15:11 | 4 | 18 |
| 4 |
|
Pumas UNAM | 9 | 5 | 2 | 2 | 16:9 | 7 | 17 |
| 5 |
|
CF Pachuca | 9 | 5 | 2 | 2 | 10:7 | 3 | 17 |
| 6 |
|
Cruz Azul | 9 | 5 | 1 | 3 | 12:10 | 2 | 16 |
| 7 |
|
Club Necaxa | 8 | 4 | 2 | 2 | 12:7 | 5 | 14 |
| 8 |
|
CF Monterrey | 9 | 4 | 2 | 3 | 15:12 | 3 | 14 |
| 9 |
|
UANL Tigres | 9 | 4 | 1 | 4 | 14:15 | -1 | 13 |
| 10 |
|
Club Tijuana | 8 | 4 | 1 | 3 | 9:10 | -1 | 13 |
| 11 |
|
Atlas Guadalajara | 9 | 4 | 0 | 5 | 24:20 | 4 | 12 |
| 12 |
|
Puebla FC | 9 | 3 | 1 | 5 | 15:17 | -2 | 10 |
| 13 |
|
Club León | 9 | 3 | 1 | 5 | 13:17 | -4 | 10 |
| 14 |
|
CF América | 9 | 3 | 0 | 6 | 11:12 | -1 | 9 |
| 15 |
|
Mazatlán FC | 9 | 3 | 0 | 6 | 14:30 | -16 | 9 |
| 16 |
|
Gallos Blancos | 9 | 2 | 2 | 5 | 11:13 | -2 | 8 |
| 17 |
|
FC Juárez | 9 | 1 | 2 | 6 | 7:17 | -10 | 5 |
| 18 |
|
Atlético San Luis | 9 | 1 | 1 | 7 | 8:28 | -20 | 4 |
| Play-off |
