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| 02.07.2022 | 18:00 | Puebla FC | - | FC Juárez | 4:0 (0:0) | |
| 18:30 | Deportivo Toluca | - | Club Necaxa | 2:0 (1:0) | ||
| 18:30 | Cruz Azul | - | CF Pachuca | 1:2 (1:0) | ||
| 18:30 | Gallos Blancos | - | Pumas UNAM | 1:2 (1:1) | ||
| 18:30 | Club León | - | UANL Tigres | 3:0 (2:0) | ||
| 21:45 | Club Tijuana | - | Santos Laguna | 2:0 (1:0) | ||
| 23:00 | CF Monterrey | - | Mazatlán FC | 4:1 (2:1) | ||
| 03.07.2022 | 18:15 | Deportivo Guadalajara | - | Atlas Guadalajara | 1:3 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 2 | 2 | 0 | 0 | 5:1 | 4 | 6 |
| 2 |
|
Pumas UNAM | 2 | 2 | 0 | 0 | 5:3 | 2 | 6 |
| 3 |
|
Deportivo Toluca | 1 | 1 | 0 | 0 | 2:0 | 2 | 3 |
| 4 |
|
Puebla FC | 2 | 1 | 0 | 1 | 4:3 | 1 | 3 |
| 5 |
|
Club Necaxa | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 |
| 6 |
|
FC Juárez | 2 | 1 | 0 | 1 | 2:4 | -2 | 3 |
| 7 |
|
Cruz Azul | 2 | 0 | 0 | 2 | 3:5 | -2 | 0 |
| 8 |
|
CF América | 1 | 0 | 0 | 1 | 0:2 | -2 | 0 |
| 9 |
|
Gallos Blancos | 2 | 0 | 0 | 2 | 1:5 | -4 | 0 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 2 | 2 | 0 | 0 | 9:1 | 8 | 6 |
| 2 |
|
Club Tijuana | 2 | 2 | 0 | 0 | 5:0 | 5 | 6 |
| 3 |
|
Atlas Guadalajara | 2 | 2 | 0 | 0 | 5:1 | 4 | 6 |
| 4 |
|
Club León | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 |
| 5 |
|
Deportivo Guadalajara | 2 | 1 | 0 | 1 | 2:3 | -1 | 3 |
| 6 |
|
Santos Laguna | 2 | 0 | 0 | 2 | 0:3 | -3 | 0 |
|
UANL Tigres | 1 | 0 | 0 | 1 | 0:3 | -3 | 0 | |
| 8 |
|
Atlético San Luis | 1 | 0 | 0 | 1 | 0:5 | -5 | 0 |
| 9 |
|
Mazatlán FC | 2 | 0 | 0 | 2 | 1:7 | -6 | 0 |
| Play-off | |
| Play-off |
