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| 30.04.2022 | 18:00 | UANL Tigres | - | Atlas Guadalajara | 1:1 (1:0) | |
| 18:15 | Deportivo Guadalajara | - | Santos Laguna | 4:0 (2:0) | ||
| 18:30 | Club León | - | CF Monterrey | 1:1 (0:1) | ||
| 18:30 | CF Pachuca | - | Deportivo Toluca | 0:2 (0:1) | ||
| 19:30 | FC Juárez | - | Gallos Blancos | 0:1 (0:0) | ||
| 20:00 | Club Necaxa | - | Pumas UNAM | 0:0 (0:0) | ||
| 21:45 | Club Tijuana | - | Mazatlán FC | 4:0 (2:0) | ||
| 23:00 | Puebla FC | - | CF América | 2:3 (2:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 15 | 10 | 5 | 0 | 33:15 | 18 | 35 |
| 2 |
|
CF Pachuca | 15 | 9 | 1 | 5 | 40:21 | 19 | 28 |
| 3 |
|
Club Necaxa | 15 | 8 | 3 | 4 | 30:18 | 12 | 27 |
| 4 |
|
Deportivo Toluca | 16 | 7 | 4 | 5 | 27:24 | 3 | 25 |
| 5 |
|
CF América | 15 | 7 | 2 | 6 | 29:23 | 6 | 23 |
| 6 |
|
FC Juárez | 15 | 6 | 2 | 7 | 20:20 | 0 | 20 |
| 7 |
|
Gallos Blancos | 15 | 5 | 2 | 8 | 14:25 | -11 | 17 |
| 8 |
|
Cruz Azul | 15 | 3 | 2 | 10 | 19:38 | -19 | 11 |
| 9 |
|
Puebla FC | 15 | 2 | 1 | 12 | 10:38 | -28 | 7 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 15 | 11 | 3 | 1 | 36:10 | 26 | 36 |
| 2 |
|
Atlas Guadalajara | 15 | 9 | 3 | 3 | 36:17 | 19 | 30 |
| 3 |
|
UANL Tigres | 15 | 9 | 2 | 4 | 29:23 | 6 | 29 |
| 4 |
|
Club Tijuana | 15 | 8 | 1 | 6 | 31:19 | 12 | 25 |
| 5 |
|
Santos Laguna | 15 | 7 | 3 | 5 | 27:26 | 1 | 24 |
| 6 |
|
CF Monterrey | 15 | 6 | 4 | 5 | 28:20 | 8 | 22 |
| 7 |
|
Club León | 15 | 5 | 4 | 6 | 20:25 | -5 | 19 |
| 8 |
|
Mazatlán FC | 16 | 1 | 1 | 14 | 13:45 | -32 | 4 |
| 9 |
|
Atlético San Luis | 15 | 1 | 1 | 13 | 4:39 | -35 | 4 |
| Play-off | |
| Play-off |
