 |
 |
|
|
| 06.11.2021 | 19:00 | Atlas Guadalajara | - | CF América | 3:2 (1:2) | |
| 19:00 | Cruz Azul | - | Club Necaxa | 1:0 (1:0) | ||
| 07.11.2021 | 17:30 | Deportivo Guadalajara | - | Gallos Blancos | 0:2 (0:1) | |
| 08.11.2021 | 00:00 | Atlético San Luis | - | CF Monterrey | 0:3 (0:2) | |
| 09.11.2021 | 00:00 | Deportivo Toluca | - | Club León | 0:3 (0:1) | |
| 02:00 | CF Pachuca | - | Santos Laguna | 4:0 (1:0) | ||
| 02:10 | UANL Tigres | - | Pumas UNAM | 2:1 (0:1) | ||
| 04:00 | Club Tijuana | - | Mazatlán FC | 5:0 (1:0) | ||
| 04:15 | FC Juárez | - | Puebla FC | 1:2 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 15 | 14 | 1 | 0 | 49:6 | 43 | 43 |
| 2 |
|
CF Monterrey | 15 | 12 | 2 | 1 | 38:9 | 29 | 38 |
| 3 |
|
Santos Laguna | 15 | 9 | 3 | 3 | 35:20 | 15 | 30 |
| 4 |
|
Deportivo Guadalajara | 15 | 9 | 3 | 3 | 30:15 | 15 | 30 |
| 5 |
|
Atlas Guadalajara | 15 | 9 | 3 | 3 | 24:15 | 9 | 30 |
| 6 |
|
CF América | 15 | 8 | 3 | 4 | 28:17 | 11 | 27 |
| 7 |
|
Club Tijuana | 15 | 7 | 3 | 5 | 22:16 | 6 | 24 |
| 8 |
|
Cruz Azul | 15 | 7 | 3 | 5 | 14:19 | -5 | 24 |
| 9 |
|
CF Pachuca | 15 | 5 | 5 | 5 | 25:22 | 3 | 20 |
| 10 |
|
Pumas UNAM | 15 | 4 | 6 | 5 | 15:15 | 0 | 18 |
| 11 |
|
Puebla FC | 15 | 4 | 3 | 8 | 17:26 | -9 | 15 |
| 12 |
|
Deportivo Toluca | 15 | 4 | 3 | 8 | 12:23 | -11 | 15 |
| 13 |
|
Club Necaxa | 15 | 4 | 2 | 9 | 12:32 | -20 | 14 |
| 14 |
|
Gallos Blancos | 15 | 3 | 4 | 8 | 15:19 | -4 | 13 |
| 15 |
|
Club León | 15 | 3 | 4 | 8 | 17:26 | -9 | 13 |
| 16 |
|
Atlético San Luis | 15 | 2 | 5 | 8 | 13:31 | -18 | 11 |
| 17 |
|
Mazatlán FC | 15 | 1 | 3 | 11 | 6:35 | -29 | 6 |
| 18 |
|
FC Juárez | 15 | 1 | 2 | 12 | 8:34 | -26 | 5 |
| Play-off |
