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| 19.05.2021 | 16:00 | ACR Messina | - | Rende | 4:1 | |
| 16:00 | Acireale | - | Paternó | 1:1 | ||
| 16:00 | Gelbison | - | US Castrovillari | 1:3 | ||
| 16:00 | Licata | - | FC Messina | 0:1 | ||
| 16:00 | Rotonda | - | Roccella | 3:3 | ||
| 16:00 | Città Di S. Agata | - | ASD Troina | 0:0 | ||
| 02.06.2021 | 16:00 | Biancavilla | - | ASD San Luca | 3:2 | |
| 16:00 | Calcio Cittanovese | - | Dattilo | 0:1 | ||
| 06.06.2021 | 16:00 | USD Ragusa | - | Santa Maria Cilento | 1:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
ACR Messina | 30 | 18 | 10 | 2 | 55:23 | 32 | 64 |
| 2 |
|
FC Messina | 30 | 17 | 9 | 4 | 46:21 | 25 | 60 |
| 3 |
|
Gelbison | 30 | 16 | 9 | 5 | 47:32 | 15 | 57 |
| 4 |
|
Acireale | 30 | 15 | 5 | 10 | 46:29 | 17 | 50 |
| 5 |
|
ASD San Luca | 30 | 14 | 7 | 9 | 39:33 | 6 | 49 |
| 6 |
|
Dattilo | 30 | 15 | 3 | 12 | 47:42 | 5 | 48 |
| 7 |
|
Rotonda | 30 | 11 | 10 | 9 | 29:30 | -1 | 43 |
| 8 |
|
Biancavilla | 30 | 13 | 3 | 14 | 35:37 | -2 | 41 |
| 9 |
|
Santa Maria Cilento | 30 | 8 | 14 | 8 | 38:26 | 12 | 38 |
| 10 |
|
Licata | 30 | 10 | 8 | 12 | 31:32 | -1 | 38 |
| 11 |
|
US Castrovillari | 30 | 9 | 10 | 11 | 35:32 | 3 | 37 |
| 12 |
|
Paternó | 30 | 9 | 9 | 12 | 24:28 | -4 | 36 |
| 13 |
|
ASD Troina | 30 | 9 | 9 | 12 | 25:36 | -11 | 36 |
| 14 |
|
Calcio Cittanovese | 30 | 8 | 9 | 13 | 34:44 | -10 | 33 |
| 15 |
|
Città Di S. Agata | 30 | 6 | 12 | 12 | 24:40 | -16 | 30 |
| 16 |
|
Rende | 30 | 8 | 6 | 16 | 31:50 | -19 | 30 |
| 17 |
|
USD Ragusa | 30 | 6 | 9 | 15 | 33:52 | -19 | 27 |
| 18 |
|
Roccella | 30 | 5 | 4 | 21 | 23:55 | -32 | 19 |
| Promotion | |
| Play-off | |
| Relégation |
