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| 16.02.2022 | 14:30 | Rotonda | - | Brindisi | 1:3 | |
| 14:30 | San Giorgio-Sedico | - | US Bitonto | 0:1 | ||
| 14:30 | Sorrento Calcio | - | FC Francavilla | 0:2 | ||
| 14:30 | ASD SS Nola 1925 | - | Lavello | 0:0 | ||
| 15:00 | Bisceglie | - | ACD Nardò | 2:1 | ||
| 15:00 | Casarano | - | Casertana FC | 3:2 | ||
| 15:00 | FBC Gravina | - | ASG Nocerina | 0:2 | ||
| 15:30 | Team Altamura | - | Audace Cerignola | 1:1 | ||
| 15:30 | Sporting Fulgor Molfetta | - | Mariglianese | 1:0 | ||
| 17:00 | Città di Fasano | - | Virtus Matino | 2:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Audace Cerignola | 24 | 15 | 7 | 2 | 53:19 | 34 | 52 |
| 2 |
|
US Bitonto | 24 | 16 | 4 | 4 | 41:22 | 19 | 52 |
| 3 |
|
FC Francavilla | 24 | 15 | 2 | 7 | 38:24 | 14 | 47 |
| 4 |
|
Città di Fasano | 24 | 13 | 5 | 6 | 47:31 | 16 | 44 |
| 5 |
|
FBC Gravina | 24 | 13 | 3 | 8 | 33:31 | 2 | 42 |
| 6 |
|
Sporting Fulgor Molfetta | 24 | 8 | 11 | 5 | 34:25 | 9 | 35 |
| 7 |
|
ASG Nocerina | 24 | 10 | 5 | 9 | 31:33 | -2 | 35 |
| 8 |
|
Sorrento Calcio | 24 | 9 | 7 | 8 | 25:31 | -6 | 34 |
| 9 |
|
Casertana FC | 24 | 9 | 6 | 9 | 38:37 | 1 | 33 |
| 10 |
|
Lavello | 24 | 8 | 6 | 10 | 33:36 | -3 | 30 |
| 11 |
|
ACD Nardò | 24 | 8 | 5 | 11 | 30:37 | -7 | 29 |
| 12 |
|
Team Altamura | 24 | 6 | 9 | 9 | 27:27 | 0 | 27 |
| 13 |
|
ASD SS Nola 1925 | 24 | 7 | 6 | 11 | 27:36 | -9 | 27 |
| 14 |
|
Mariglianese | 24 | 7 | 5 | 12 | 27:30 | -3 | 26 |
| 15 |
|
San Giorgio-Sedico | 24 | 6 | 8 | 10 | 18:24 | -6 | 26 |
| 16 |
|
Rotonda | 24 | 9 | 6 | 9 | 25:26 | -1 | 25 |
| 17 |
|
Casarano | 24 | 6 | 7 | 11 | 24:34 | -10 | 25 |
| 18 |
|
Bisceglie | 24 | 4 | 12 | 8 | 20:31 | -11 | 24 |
| 19 |
|
Brindisi | 24 | 5 | 6 | 13 | 19:38 | -19 | 21 |
| 20 |
|
Virtus Matino | 24 | 4 | 4 | 16 | 18:36 | -18 | 16 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
