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| 08.12.2021 | 14:30 | ASG Nocerina | - | Virtus Matino | 2:1 | |
| 14:30 | US Bitonto | - | Audace Cerignola | 0:0 | ||
| 14:30 | Brindisi | - | ACD Nardò | 1:1 | ||
| 14:30 | Città di Fasano | - | ASD SS Nola 1925 | 1:1 | ||
| 14:30 | FC Francavilla | - | Casertana FC | 2:1 | ||
| 14:30 | Mariglianese | - | Lavello | 3:0 | ||
| 14:30 | Sporting Fulgor Molfetta | - | Team Altamura | 0:0 | ||
| 14:30 | Rotonda | - | FBC Gravina | 0:1 | ||
| 14:30 | San Giorgio-Sedico | - | Casarano | 1:1 | ||
| 14:30 | Sorrento Calcio | - | Bisceglie | 2:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Audace Cerignola | 15 | 9 | 4 | 2 | 31:11 | 20 | 31 |
| 2 |
|
FC Francavilla | 15 | 10 | 1 | 4 | 27:16 | 11 | 31 |
| 3 |
|
US Bitonto | 15 | 8 | 4 | 3 | 21:14 | 7 | 28 |
| 4 |
|
ASG Nocerina | 15 | 8 | 3 | 4 | 22:19 | 3 | 27 |
| 5 |
|
Casertana FC | 15 | 7 | 5 | 3 | 25:19 | 6 | 26 |
| 6 |
|
FBC Gravina | 15 | 8 | 1 | 6 | 19:18 | 1 | 25 |
| 7 |
|
Città di Fasano | 15 | 7 | 3 | 5 | 24:16 | 8 | 24 |
| 8 |
|
Lavello | 15 | 7 | 3 | 5 | 27:24 | 3 | 24 |
| 9 |
|
Mariglianese | 15 | 6 | 3 | 6 | 21:18 | 3 | 21 |
| 10 |
|
Sorrento Calcio | 15 | 5 | 6 | 4 | 14:18 | -4 | 21 |
| 11 |
|
Sporting Fulgor Molfetta | 15 | 4 | 7 | 4 | 12:15 | -3 | 19 |
| 12 |
|
Rotonda | 15 | 7 | 4 | 4 | 16:10 | 6 | 17 |
| 13 |
|
Casarano | 15 | 4 | 4 | 7 | 10:15 | -5 | 16 |
| 14 |
|
Bisceglie | 15 | 3 | 7 | 5 | 8:15 | -7 | 16 |
| 15 |
|
ASD SS Nola 1925 | 15 | 4 | 4 | 7 | 14:27 | -13 | 16 |
| 16 |
|
ACD Nardò | 15 | 4 | 3 | 8 | 17:22 | -5 | 15 |
| 17 |
|
Team Altamura | 15 | 3 | 5 | 7 | 17:20 | -3 | 14 |
| 18 |
|
San Giorgio-Sedico | 15 | 2 | 8 | 5 | 10:14 | -4 | 14 |
| 19 |
|
Brindisi | 15 | 1 | 5 | 9 | 10:22 | -12 | 8 |
| 20 |
|
Virtus Matino | 15 | 2 | 2 | 11 | 8:20 | -12 | 8 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
