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| 18.04.2021 | 15:00 | ACD Nardò | - | Portici 1906 | 3:0 | |
| 15:00 | Brindisi | - | FC Francavilla | 1:2 | ||
| 15:00 | Casarano | - | Sporting Fulgor Molfetta | 1:1 | ||
| 15:00 | Città di Fasano | - | Taranto FC | 1:2 | ||
| 15:00 | FBC Gravina | - | Fidelis Andria | 0:2 | ||
| 15:00 | AZ Picerno | - | US Bitonto | 2:1 | ||
| 15:00 | Puteolana Internapoli | - | Lavello | 1:1 | ||
| 15:00 | Aversa Normanna | - | Team Altamura | 1:1 | ||
| 15:00 | Sorrento Calcio | - | Audace Cerignola | 2:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Taranto FC | 27 | 15 | 10 | 2 | 36:14 | 22 | 55 |
| 2 |
|
AZ Picerno | 27 | 13 | 10 | 4 | 43:30 | 13 | 49 |
| 3 |
|
Casarano | 27 | 13 | 9 | 5 | 43:24 | 19 | 48 |
| 4 |
|
Fidelis Andria | 27 | 12 | 10 | 5 | 31:16 | 15 | 46 |
| 5 |
|
Lavello | 27 | 12 | 9 | 6 | 46:31 | 15 | 45 |
| 6 |
|
Team Altamura | 27 | 11 | 9 | 7 | 41:30 | 11 | 42 |
| 7 |
|
ACD Nardò | 27 | 12 | 6 | 9 | 37:28 | 9 | 42 |
| 8 |
|
US Bitonto | 27 | 12 | 6 | 9 | 37:33 | 4 | 42 |
| 9 |
|
Sporting Fulgor Molfetta | 27 | 11 | 8 | 8 | 44:39 | 5 | 41 |
| 10 |
|
Audace Cerignola | 27 | 9 | 10 | 8 | 41:30 | 11 | 37 |
| 11 |
|
Sorrento Calcio | 27 | 9 | 8 | 10 | 29:41 | -12 | 35 |
| 12 |
|
Città di Fasano | 27 | 6 | 10 | 11 | 27:34 | -7 | 28 |
| 13 |
|
FC Francavilla | 27 | 6 | 9 | 12 | 31:42 | -11 | 27 |
| 14 |
|
Aversa Normanna | 27 | 7 | 5 | 15 | 29:43 | -14 | 26 |
| 15 |
|
Brindisi | 27 | 6 | 9 | 12 | 20:36 | -16 | 25 |
| 16 |
|
FBC Gravina | 27 | 5 | 9 | 13 | 23:30 | -7 | 24 |
| 17 |
|
Puteolana Internapoli | 27 | 4 | 9 | 14 | 20:45 | -25 | 21 |
| 18 |
|
Portici 1906 | 27 | 5 | 4 | 18 | 32:64 | -32 | 19 |
| Promotion | |
| Play-off | |
| Relégation |
