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| 07.02.2021 | 14:30 | Audace Cerignola | - | Taranto FC | 0:0 | |
| 14:30 | US Bitonto | - | ACD Nardò | 1:0 | ||
| 14:30 | Brindisi | - | Casarano | 0:3 | ||
| 14:30 | FC Francavilla | - | Team Altamura | 0:2 | ||
| 14:30 | Lavello | - | Fidelis Andria | 1:0 | ||
| 14:30 | AZ Picerno | - | Città di Fasano | 2:2 | ||
| 14:30 | Puteolana Internapoli | - | Aversa Normanna | 0:0 | ||
| 17.03.2021 | 14:30 | Sporting Fulgor Molfetta | - | Portici 1906 | 3:0 | |
| 24.03.2021 | 14:30 | Sorrento Calcio | - | FBC Gravina | 1:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Casarano | 16 | 9 | 5 | 2 | 30:15 | 15 | 32 |
| 2 |
|
Taranto FC | 16 | 8 | 7 | 1 | 22:10 | 12 | 31 |
| 3 |
|
Lavello | 16 | 7 | 7 | 2 | 29:17 | 12 | 28 |
| 4 |
|
AZ Picerno | 16 | 7 | 7 | 2 | 24:15 | 9 | 28 |
| 5 |
|
Team Altamura | 16 | 8 | 3 | 5 | 29:20 | 9 | 27 |
| 6 |
|
Sorrento Calcio | 16 | 7 | 6 | 3 | 20:17 | 3 | 27 |
| 7 |
|
Fidelis Andria | 16 | 7 | 5 | 4 | 18:11 | 7 | 26 |
| 8 |
|
Sporting Fulgor Molfetta | 16 | 6 | 4 | 6 | 19:20 | -1 | 22 |
| 9 |
|
ACD Nardò | 16 | 6 | 4 | 6 | 15:19 | -4 | 22 |
| 10 |
|
US Bitonto | 16 | 6 | 3 | 7 | 18:20 | -2 | 21 |
| 11 |
|
FC Francavilla | 16 | 4 | 6 | 6 | 13:19 | -6 | 18 |
| 12 |
|
Brindisi | 16 | 5 | 5 | 6 | 13:20 | -7 | 18 |
| 13 |
|
Audace Cerignola | 16 | 3 | 8 | 5 | 17:16 | 1 | 17 |
| 14 |
|
Aversa Normanna | 16 | 4 | 3 | 9 | 18:24 | -6 | 15 |
| 15 |
|
FBC Gravina | 16 | 3 | 5 | 8 | 17:20 | -3 | 14 |
| 16 |
|
Portici 1906 | 16 | 4 | 2 | 10 | 26:37 | -11 | 14 |
| 17 |
|
Puteolana Internapoli | 16 | 2 | 6 | 8 | 10:24 | -14 | 12 |
| 18 |
|
Città di Fasano | 16 | 2 | 6 | 8 | 9:23 | -14 | 12 |
| Promotion | |
| Play-off | |
| Relégation |
