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| 03.10.2021 | 15:00 | Arzachena | - | CynthiAlbalonga | 1:0 | |
| 15:00 | ASD Carbonia Calcio | - | Formia | 3:3 | ||
| 15:00 | FC Aprilia | - | Afragolese | 1:0 | ||
| 15:00 | Gladiator | - | Sassari Latte Dolce | 1:1 | ||
| 15:00 | Team Nuova Florida | - | Giugliano | 0:3 | ||
| 15:00 | Ostia Mare | - | Real Monterotondo Scalo | 0:0 | ||
| 15:00 | SEF Torres 1903 | - | Cassino Calcio 1924 | 4:0 | ||
| 15:00 | ASD Vis Artena | - | Atletico Uri | 1:2 | ||
| 16:00 | Muravera | - | Lanusei Calcio | 1:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Giugliano | 3 | 3 | 0 | 0 | 5:0 | 5 | 9 |
| 2 |
|
Arzachena | 3 | 2 | 1 | 0 | 5:2 | 3 | 7 |
| 3 |
|
FC Aprilia | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 4 |
|
Afragolese | 3 | 2 | 0 | 1 | 5:1 | 4 | 6 |
| 5 |
|
Muravera | 3 | 2 | 0 | 1 | 5:4 | 1 | 6 |
| 6 |
|
Cassino Calcio 1924 | 3 | 2 | 0 | 1 | 4:6 | -2 | 6 |
| 7 |
|
Team Nuova Florida | 3 | 2 | 0 | 1 | 4:4 | 0 | 6 |
| 8 |
|
Gladiator | 3 | 1 | 2 | 0 | 8:6 | 2 | 5 |
| 9 |
|
Sassari Latte Dolce | 3 | 1 | 2 | 0 | 4:3 | 1 | 5 |
| 10 |
|
SEF Torres 1903 | 3 | 1 | 1 | 1 | 4:1 | 3 | 4 |
| 11 |
|
Atletico Uri | 3 | 1 | 0 | 2 | 5:6 | -1 | 3 |
| 12 |
|
Lanusei Calcio | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 |
| 13 |
|
Ostia Mare | 3 | 0 | 2 | 1 | 0:1 | -1 | 2 |
| 14 |
|
CynthiAlbalonga | 3 | 0 | 1 | 2 | 0:2 | -2 | 1 |
| 15 |
|
Real Monterotondo Scalo | 3 | 0 | 1 | 2 | 4:7 | -3 | 1 |
| 16 |
|
Formia | 3 | 0 | 1 | 2 | 3:7 | -4 | 1 |
| 17 |
|
ASD Carbonia Calcio | 3 | 0 | 2 | 1 | 4:7 | -3 | 1 |
| 18 |
|
ASD Vis Artena | 3 | 0 | 0 | 3 | 1:5 | -4 | 0 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
